PILRA anticorps (N-Term)

N° du produit ABIN2782793

Détail du produit anti-PILRA anticorps

Antigène: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PILRA est non-conjugé

Application: Western Blotting (WB)

Séquence: IPFSFYYPWE LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN

Specificité: 100 % homologous to all four isoforms of human PILRA.

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PILRA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PILRA

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 175 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PILRA

Antigène: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Autre désignation: PILRA (PILRA Produits)

Synonymes: anticorps PILRA, anticorps FDF03, anticorps AV021745, anticorps RGD1562847, anticorps paired immunoglobin like type 2 receptor alpha, anticorps paired immunoglobulin-like type 2 receptor alpha, anticorps paired immunoglobin-like type 2 receptor alpha, anticorps PILRA, anticorps LOC489841, anticorps Pilra

Sujet: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Alias Symbols: FDF03
Protein Interaction Partner: DNPH1, SORBS1, PTPN6, PTPN11, FCAR,
Protein Size: 175

Poids moléculaire: 18 kDa

ID gène: 29992

NCBI Accession: NM_178273, NP_840057