GADD45B anticorps (Middle Region)

N° du produit ABIN2783334

Détail du produit anti-GADD45B anticorps

Antigène: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GADD45B est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Séquence: FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GADD45B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GADD45B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 160 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-GADD45B (ABIN2783334)

Ursini, Cavalleri, Fazio, Angrisano, Iacovelli, Porcelli, Maddalena, Punzi, Mancini, Gelao, Romano, Masellis, Calabrese, Rampino, Taurisano, Di Giorgio, Keller, Tarantini, Sinibaldi, Quarto et al.: "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..." dans: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016) (PubMed).

Gavin, Kusumo, Zhang, Guidotti, Pandey: "Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors." dans: Alcoholism, clinical and experimental research, Vol. 40, Issue 2, pp. 263-72, (2016) (PubMed).

Matrisciano, Dong, Gavin, Nicoletti, Guidotti: "Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain." dans: Molecular pharmacology, Vol. 80, Issue 1, pp. 174-82, (2011) (PubMed).

Gavin, Sharma, Chase, Matrisciano, Dong, Guidotti: "Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis." dans: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 2, pp. 531-42, (2011) (PubMed).

Tornatore, Marasco, Dathan, Vitale, Benedetti, Papa, Franzoso, Ruvo, Monti: "Gadd45 beta forms a homodimeric complex that binds tightly to MKK7." dans: Journal of molecular biology, Vol. 378, Issue 1, pp. 97-111, (2008) (PubMed).

Détails sur GADD45B

Antigène: GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))

Autre désignation: GADD45B (GADD45B Produits)

Synonymes: anticorps GADD45BETA, anticorps MYD118, anticorps AI323528, anticorps Myd118, anticorps CS131, anticorps cb196, anticorps gadd45b, anticorps gadd45b2, anticorps sb:cb196, anticorps zgc:73104, anticorps gadd45beta, anticorps wu:fa92d10, anticorps wu:fa98h12, anticorps wu:fk65h03, anticorps zgc:111973, anticorps gadd45b1, anticorps gadd45bl, anticorps zgc:112453, anticorps growth arrest and DNA damage inducible beta, anticorps growth arrest and DNA-damage-inducible 45 beta, anticorps growth arrest and DNA-damage-inducible, beta, anticorps growth arrest and DNA-damage-inducible, beta a, anticorps growth arrest and DNA-damage-inducible, beta b, anticorps GADD45B, anticorps Gadd45b, anticorps gadd45ba, anticorps gadd45bb

Sujet: The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZP566B133, GADD45BETA, MYD118
Protein Interaction Partner: UBD, UBC, MAP3K4, GADD45GIP1, GADD45G, MAP2K7, MAP3K5, PPARG, PPARD, PCNA, PPARA, ESR1, CCNB1, CDK1, CDKN1A, GADD45A, EGR1,
Protein Size: 160

Poids moléculaire: 18 kDa

ID gène: 4616

NCBI Accession: NM_015675, NP_056490

UniProt: O75293

Pathways: Cycle Cellulaire