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MAP4K4 anticorps (N-Term)

MAP4K4 Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783612
  • Antigène Voir toutes MAP4K4 Anticorps
    MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
    Épitope
    • 22
    • 10
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 65
    • 17
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio)
    Hôte
    • 61
    • 4
    Lapin
    Clonalité
    • 60
    • 5
    Polyclonal
    Conjugué
    • 33
    • 5
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAP4K4 est non-conjugé
    Application
    • 36
    • 34
    • 15
    • 15
    • 10
    • 10
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    PFIRDQPNER QVRIQLKDHI DRTRKKRGEK DETEYEYSGS EEEEEEVPEQ
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MAP4K4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP4K4
    Top Product
    Discover our top product MAP4K4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 1166 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
    Autre désignation
    MAP4K4 (MAP4K4 Produits)
    Synonymes
    anticorps FLH21957, anticorps HGK, anticorps MEKKK4, anticorps NIK, anticorps 9430080K19Rik, anticorps AU043147, anticorps AU045934, anticorps AW046177, anticorps Nik, anticorps mitogen-activated protein kinase kinase kinase kinase 4, anticorps MAP4K4, anticorps Map4k4
    Sujet
    MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
    Alias Symbols: FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK, MEKKK4
    Protein Interaction Partner: UBC, MOB1B, NME7, PPP1CC, HSP90AA1, PAXIP1, GRK5, TRAPPC9, PPP1CA, KIF26B, HIST2H2BE, SLC9A1, PRKCE, KIF5A, ZRANB1, DOK1, MAP3K7, NCK1, GBP3, RAP2A, RASA1, ITGB1, MAP3K1, BRCA1, ATL1,
    Protein Size: 1239
    Poids moléculaire
    142 kDa
    ID gène
    9448
    NCBI Accession
    NM_004834, NP_004825
    UniProt
    O95819
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