TAB1 anticorps (N-Term)
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- Antigène Voir toutes TAB1 Anticorps
- TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Porc, Chien, Lapin, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAB1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
- Homologie
- Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against MAP3K7IP1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1
- Top Product
- Discover our top product TAB1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 462 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
- Autre désignation
- MAP3K7IP1 (TAB1 Produits)
- Sujet
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The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1
Protein Interaction Partner: MAGED1, BAG2, MAP3K7, TIRAP, MDM2, SLMAP, NPM1, BIRC3, TRIP6, PPP2R1A, PPP2CB, GRB2, FN1, CDK5RAP3, TAB2, CORO1A, WTAP, MAPK8IP1, UBC, MAPK14, BST2, MAPK12, HSP90AA1, NOTCH1, IKBKB, GRK5, EGFR, STE11, BIRC7, NAIP, XIAP, OGT, TAB3, NR2C2, ARRB2, ARAP1, ACA
Protein Size: 462 - Poids moléculaire
- 50 kDa
- ID gène
- 10454
- NCBI Accession
- NM_153497, NP_705717
- UniProt
- Q8IZW2
- Pathways
- Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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