GNAI1 anticorps (Middle Region)

N° du produit ABIN2785808

Détail du produit anti-GNAI1 anticorps

Antigène: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Cobaye, Chien, Lapin, Poisson zèbre (Danio rerio), Cheval, Chévre, Saccharomyces cerevisiae, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNAI1 est non-conjugé

Application: Western Blotting (WB)

Séquence: YQLNDSAAYY LNDLDRIAQP NYIPTQQDVL RTRVKTTGIV ETHFTFKDLH

Homologie: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%, Yeast: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against GNAI1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GNAI1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 354 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GNAI1

Antigène: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Autre désignation: GNAI1 (GNAI1 Produits)

Synonymes: anticorps AU046200, anticorps Gialpha1, anticorps Gnai-1, anticorps gnai1, anticorps Gi, anticorps BPGTPB, anticorps zgc:63957, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting 1, anticorps G protein subunit alpha i1, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 S homeolog, anticorps guanine nucleotide-binding protein G(i) subunit alpha-1, anticorps guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1, anticorps Gnai1, anticorps gnai1.S, anticorps GNAI1, anticorps LOC397505, anticorps gnai1

Sujet: Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase, Go, a protein abundant in brain (GNAO1), and transducin-1 (GNAT1) and transducin-2 (GNAT2), proteins involved in phototransduction in retinal rods and cones, respectively.Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase, Go, a protein abundant in brain (GNAO1, MIM 139311), and transducin-1 (GNAT1, MIM 139330) and transducin-2 (GNAT2, MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218], Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein, see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Gi
Protein Interaction Partner: GPSM3, RGS17, ESR1, ATP4A, RAD52, SVIL, NUCB1, NCF2, MTNR1B, MTNR1A, NCF1, THAP7, RIC8A, RGS14, IQCB1, UBC, RANGAP1, GPR50, GNB1, GNAI3, GNAI2, GNB4, GNB2, PTH1R, PCK1, Haus1, Cep76, Haus4, Recql4, Trim69, Cbx1, PGR, STRN, KLHL3, ADCY5, RASD1, CRHR1, GPSM
Protein Size: 354

Poids moléculaire: 40 kDa

ID gène: 2770

NCBI Accession: NM_002069, NP_002060

UniProt: P63096

Pathways: G-protein mediated Events