TNFRSF4 anticorps (Middle Region)

N° du produit ABIN2787930

Détail du produit anti-TNFRSF4 anticorps

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Épitope: Middle Region

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNFRSF4 est non-conjugé

Application: Western Blotting (WB)

Séquence: GKHTLQPASN SSDAICEDRD PPATQPQETQ GPPARPITVQ PTEAWPRTSQ

Homologie: Human: 100%, Pig: 86%

Attributs du produit: This is a rabbit polyclonal antibody against TNFRSF4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TNFRSF4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 277 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TNFRSF4

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Autre désignation: TNFRSF4 (TNFRSF4 Produits)

Synonymes: anticorps TNFRSF4, anticorps ACT35, anticorps CD134, anticorps Ly-70, anticorps Ox40, anticorps TXGP1L, anticorps Txgp1, anticorps OX40, anticorps TNF receptor superfamily member 4, anticorps tumor necrosis factor receptor superfamily, member 4, anticorps TNFRSF4, anticorps Tnfrsf4

Sujet: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Alias Symbols: ACT35, CD134, OX40, TXGP1L
Protein Interaction Partner: TRAF4, TRAF5, TRAF3, TRAF2, TRAF1, TNFRSF9, SIVA1, TNFSF4,
Protein Size: 277

Poids moléculaire: 27 kDa

ID gène: 7293

NCBI Accession: NM_003327, NP_003318

UniProt: P43489

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints