CD137 anticorps

N° du produit ABIN2800694

Détail du produit anti-CD137 anticorps

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD137 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Specificité: The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

niveau d'endotoxine: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogène: Recombinant human CD137 ectodomain

Clone: 4B4-1

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional application: Inhibition of cytokine production.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD137 (ABIN2800694)

Yi, Zhao, Wang, Dai, Hellström, Hellström, Zhang: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." dans: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).

Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." dans: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, (2012) (PubMed).

Chan, Voskens, Lin, Schindler, Azimzadeh, Wang, Taylor, Strome, Schulze: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." dans: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, (2009) (PubMed).

Détails sur CD137

Antigène: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Autre désignation: CD137 / 4-1BB (TNFRSF9 Produits)

Synonymes: anticorps TNFRSF9, anticorps zgc:136557, anticorps 4-1BB, anticorps CD137, anticorps CDw137, anticorps ILA, anticorps A930040I11Rik, anticorps AA408498, anticorps AI325004, anticorps Cd137, anticorps Ly63, anticorps tumor necrosis factor receptor superfamily member 9, anticorps TNF receptor superfamily member 9, anticorps tumor necrosis factor receptor superfamily, member 9a, anticorps tumor necrosis factor receptor superfamily, member 9, anticorps TNFRSF9, anticorps tnfrsf9a, anticorps Tnfrsf9

Sujet: TNF receptor superfamily member 9,CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.,TNFRSF9, 41BB, 4-1BB, MGC2172

ID gène: 3604

UniProt: Q07011

Pathways: Cancer Immune Checkpoints