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LAT anticorps (Cytoplasmic Domain)

LAT Reactivité: Humain WB, IP, FACS Hôte: Souris Monoclonal LAT-01 unconjugated
N° du produit ABIN302069
  • Antigène Voir toutes LAT Anticorps
    LAT (Linker For Activation of T Cells (LAT))
    Épitope
    • 19
    • 15
    • 15
    • 8
    • 8
    • 7
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reactivité
    • 134
    • 59
    • 41
    • 1
    • 1
    Humain
    Hôte
    • 117
    • 17
    • 2
    • 1
    Souris
    Clonalité
    • 119
    • 18
    Monoclonal
    Conjugué
    • 65
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Cet anticorp LAT est non-conjugé
    Application
    • 74
    • 41
    • 39
    • 39
    • 18
    • 12
    • 10
    • 9
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)
    Specificité
    The antibody LAT-01 reacts with an intracellular epitope of LAT, a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
    Aucune reactivité croisée
    Souris
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.
    Clone
    LAT-01
    Isotype
    IgG1
  • Indications d'application
    Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized.
    Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized.
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

    Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." dans: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

  • Antigène
    LAT (Linker For Activation of T Cells (LAT))
    Autre désignation
    LAT (LAT Produits)
    Synonymes
    anticorps LAT, anticorps lat, anticorps LAT1, anticorps pp36, anticorps linker for activation of T-cells, anticorps linker for activation of T cells, anticorps LAT, anticorps lat, anticorps Lat
    Sujet
    Linker for activation of T cells,LAT (linker for activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.,IMD52
    ID gène
    27040
    UniProt
    O43561
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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