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MCTS1 anticorps

MCTS1 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN303009
  • Antigène Voir toutes MCTS1 Anticorps
    MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
    Reactivité
    • 49
    • 13
    • 11
    • 7
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 2
    • 1
    Lapin
    Clonalité
    • 49
    • 2
    Polyclonal
    Conjugué
    • 28
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MCTS1 est non-conjugé
    Application
    • 43
    • 18
    • 16
    • 14
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody residues 3-14[KKFDEKENVSNC] of the 20 kDa MCT-1 protein.
    Purification
    Immunoaffinity Chromatography
    Immunogène
    Synthetic peptide
    Isotype
    IgG
    Top Product
    Discover our top product MCTS1 Anticorps primaire
  • Indications d'application
    Immunohistochemistry on paraffin sections: 20 μg/mL. Western Blot: 1: 500 - 1: 1000. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
    Autre désignation
    MCTS1 (MCTS1 Produits)
    Synonymes
    anticorps MCT-1, anticorps MCT1, anticorps MCT1a, anticorps cb517, anticorps zgc:55682, anticorps 1500019M23Rik, anticorps zgc:56242, anticorps mcts1, anticorps MGC89874, anticorps MCTS1, anticorps MCT-1A, anticorps mct-1, anticorps mct1, anticorps MCT-1B, anticorps mcts1-a, anticorps mcts1-b, anticorps MCTS1, re-initiation and release factor, anticorps solute carrier family 16 (monocarboxylate transporter), member 1b, anticorps malignant T cell amplified sequence 1, anticorps malignant T-cell amplified sequence 1, anticorps solute carrier family 16 member 1, anticorps malignant T-cell amplified sequence 1 S homeolog, anticorps monocarboxylate transporter 1, anticorps malignant T-cell amplified sequence 1 L homeolog, anticorps MCTS1, anticorps slc16a1b, anticorps Mcts1, anticorps mcts1, anticorps SLC16A1, anticorps mcts1.S, anticorps MCT1, anticorps mcts1.L
    Sujet
    Malignant T cell amplified sequence 1 (MCTS1) is an anti-oncogene that plays a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer, and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.Synonyms: MCT-1, MCT1, MCTS1, Malignant T cell amplified sequence 1
    ID gène
    28985
    NCBI Accession
    NP_001131026
    UniProt
    Q9ULC4
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