anti-Oazin (Antizyme inhibitor 1) anticorps

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	Antigène:	Oazin (Antizyme inhibitor 1)
	Clonalité:	Monoclonal (HI-12)
	Application:	Western Blotting (WB), Immunocytochemistry (ICC)
	Reactivité:	Human, Mouse (Murine), Rat (Rattus)
	Hôte:	Mouse
	Quantité:	50 ug (0.25 mg/ml)
	Prix:	739,04 € (Plus frais de livraison et TVA)
	Numéro du produit:	ABIN303592
	Disponibilité:	Envoi sous 5 jours ouvrables

Antigène	Oazin (Antizyme inhibitor 1)
Immunogène	Affinity-purified Antizyme inhibitor from rat liver
Reactivité	Human, Mouse (Murine), Rat (Rattus)
Clonalité	Monoclonal
Format	Ion exchange chromatography
Isotype	IgG3 »Anticorps secondaires correspondants
Description	ODC (ornithine decarboxylase) is a key enzyme in polyamine biosynthesis pathway. The degradation of ODC catalyzed by the 26S proteasome is accelerated by antizyme, an ODC inhibitory protein induced poliamine. Antizyme inhibitor 1 (AZI) specifically binds to antizyme with a higher affinity than that of ODC and thus can release active ODC from inactive ODC-antizyme complex. AZI consists of about 450 amino acids and 50 kDa protein. AZI is highly homologous to ODC but retains no enzymatic activity. AZI is a short-living protein that undergoes proteasomal degradation and the degradation is inhibited by interaction with antizyme. AZI is induced in cells and tissues following growth stimulation, is elevated in some tumors. AZI overexpression leads to increased rates of cell proliferation in the rat carcinoma cells and mouse fibroblasts and this effect appears to be partially independent of the ability of AZI to interact with antizyme. It has been also reported that antizyme and AZI localize to centrosome and may play an important role in the regulation of centrosome homeostasis and oncogenesis.
Clone	HI-12
Hôte	Mouse

Application	Western Blotting (WB), Immunocytochemistry (ICC)
Indications d'application	WB: 0.25 ug/mL. ICC 30 ug/mL
Concentration	0.25 mg/ml
Purification	Ion exchange chromatography
Buffer	PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Stock	Store below
Domaine de recherche	Enzymes, Metabolismus, Proteasome
Restrictions	For Research Use only