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Ki-67 anticorps (C-Term)

MKI67 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042997
  • Antigène Voir toutes Ki-67 (MKI67) Anticorps
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Épitope
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 12
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3234-3256, C-Term
    Reactivité
    • 216
    • 96
    • 61
    • 16
    • 15
    • 5
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 159
    • 52
    • 12
    • 3
    Lapin
    Clonalité
    • 150
    • 74
    Polyclonal
    Conjugué
    • 97
    • 15
    • 14
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp Ki-67 est non-conjugé
    Application
    • 92
    • 89
    • 67
    • 65
    • 55
    • 52
    • 43
    • 33
    • 30
    • 16
    • 15
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Antigen KI-67(MKI67) detection. Tested with WB in Human.
    Séquence
    KKAEDNVCVK KIRTRSHRDS EDI
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Antigen KI-67(MKI67) detection. Tested with WB in Human.
    Gene Name: antigen identified by monoclonal antibody Ki-67
    Protein Name: Antigen KI-67
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human Ki67(3234-3256aa KKAEDNVCVKKIRTRSHRDSEDI).
    Isotype
    IgG
    Top Product
    Discover our top product MKI67 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MKI67 is approximately 1 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Lu, Wang, Zhang, Liu, Li, Zhang, Ye, Zhao, Zhao, Yan, Yang, Zhang, Li, Ren: "HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth." dans: Oncotarget, Vol. 7, Issue 17, pp. 23594-607, (2018) (PubMed).

    Chen, Li, Peng, Jie, Dongye, Cai, Feng, Li, Zeng, Lun, Chen, Xu: "The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex." dans: Oncotarget, Vol. 7, Issue 49, pp. 80716-80734, (2018) (PubMed).

    Shi, Lv, Nie, Lu, Liu, Tian, Li, Zhang, Ren, Zhang, Kang: "Human nail stem cells are retained but hypofunctional during aging." dans: Journal of molecular histology, Vol. 49, Issue 3, pp. 303-316, (2018) (PubMed).

    Sun, Zhang, Wang, Shang, Zhou, Wang, Duan, Ruan, Gao, Dai, Qu, Liu, Ding, Wang, Wang, Dou: "MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis." dans: Oncotarget, Vol. 7, Issue 10, pp. 11595-608, (2017) (PubMed).

    Zhou, Wang, Xu, Wan, Qu, Fan, Chen, Sun, Liu: "Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo." dans: Oncotarget, Vol. 7, Issue 14, pp. 18620-30, (2017) (PubMed).

    Jiang, He, Wang, Zhang, Zhang, Yan, Wang, Che, Ke, Chen, Tong, Zhang, Wang, Li, Wan: "Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing." dans: Oncotarget, Vol. 6, Issue 42, pp. 44660-74, (2016) (PubMed).

    Gao, Shen, He, Xiao: "GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins." dans: International journal of molecular medicine, Vol. 36, Issue 5, pp. 1282-90, (2016) (PubMed).

    Han, Wu, Wu, Huang, Cheng, Li, Sun, Xie, Zhou, Du: "Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling." dans: Cell death & disease, Vol. 7, pp. e2123, (2016) (PubMed).

    Zeng, Zhao, Ouyang, Zhao, Zhang, Chen, Yu, Lei: "Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cultivated in serum-free medium." dans: Oncology letters, Vol. 12, Issue 2, pp. 815-824, (2016) (PubMed).

    Li, Zeng, Qi, Tang, Zhang, Wu, Liang, Shi, Liu, Zhang: "Xenotransplantation of human adipose-derived stem cells in zebrafish embryos." dans: PLoS ONE, Vol. 10, Issue 4, pp. e0123264, (2015) (PubMed).

    Alsaegh, Miyashita, Zhu: "Expression of human papillomavirus is correlated with Ki-67 and COX-2 expressions in keratocystic odontogenic tumor." dans: Pathology oncology research : POR, Vol. 21, Issue 1, pp. 65-71, (2015) (PubMed).

    Li, Wang, Wu, Yang, Zhao, Chen, Xie, Li, Wei, Huang, Zhou, Du: "miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells." dans: Cellular and molecular neurobiology, Vol. 35, Issue 5, pp. 679-87, (2015) (PubMed).

    Liu, Wang, Wang: "Controllable organization and high throughput production of recoverable 3D tumors using pneumatic microfluidics." dans: Lab on a chip, Vol. 15, Issue 4, pp. 1195-204, (2015) (PubMed).

    Huang, Ma, Xu, Li, Li, Yue, Li, Guo, Qi: "Wnt2 promotes non-small cell lung cancer progression by activating WNT/?-catenin pathway." dans: American journal of cancer research, Vol. 5, Issue 3, pp. 1032-46, (2015) (PubMed).

    Cheng, Wang, Li, Wu, Han, Li, Chen, Xie, Huang, Du, Zhou: "MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma." dans: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 27, (2015) (PubMed).

    Xie, Zhu, Yang, Huang, Wu, Wang, Luo, Wang, Shao: "Solamargine triggers hepatoma cell death through apoptosis." dans: Oncology letters, Vol. 10, Issue 1, pp. 168-174, (2015) (PubMed).

    Yu, Chen, Su, Huo, Lin, Liao: "Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas: a retrospective cohort study." dans: International journal of ophthalmology, Vol. 8, Issue 6, pp. 1224-8, (2015) (PubMed).

    Shan, Li, Newton, Zhao, Li, Guo: "A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells." dans: Toxicology letters, Vol. 227, Issue 2, pp. 129-38, (2014) (PubMed).

    Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." dans: Carcinogenesis, Vol. 35, Issue 8, pp. 1901-10, (2014) (PubMed).

    Duan, Lin, Li, Ding, Qian, Zhang, Ge, Fan, Li: "Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells." dans: Cancer biology & therapy, Vol. 15, Issue 5, pp. 544-59, (2014) (PubMed).

  • Antigène
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Autre désignation
    MKI67 (MKI67 Produits)
    Synonymes
    anticorps MKI67, anticorps kia, anticorps mki67, anticorps MGC132156, anticorps D630048A14Rik, anticorps Ki-67, anticorps Ki67, anticorps KIA, anticorps MIB-1, anticorps marker of proliferation Ki-67, anticorps marker of proliferation Ki-67 L homeolog, anticorps marker of proliferation Ki-67 S homeolog, anticorps antigen identified by monoclonal antibody Ki 67, anticorps antigen identified by monoclonal antibody Ki-67, anticorps nucleolar protein interacting with the FHA domain of MKI67, anticorps MKI67, anticorps mki67, anticorps mki67.L, anticorps mki67.S, anticorps Mki67, anticorps NIFK
    Sujet
    Ki-67(Proliferation-related Ki-67 antigen), also known as MKI67 or KIA, is a protein that in humans is encoded by the MKI67 gene. From study of a panel of human-rodent somatic cell hybrids, Schonk et al.(1989) demonstrated that a gene involved in the expression of the MKI67 antigen is located on chromosome 10. By in situ hybridization, Fonatsch et al.(1991) regionalized the MKI67 gene to chromosome 10q25-qter. By FISH, Traut et al.(1998) mapped the mouse Mki67 gene to chromosome 7F3-F5. Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore it is associated with ribosomal RNA transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis.

    Synonyms: Antigen identified by monoclonal antibody Ki 67 antibody|Antigen KI-67 antibody|Antigen KI67 antibody|KI67_HUMAN antibody|KIA antibody|MKI67 antibody|Proliferation related Ki 67 antigen antibody|RP11-380J17.2 antibody
    UniProt
    P46013
    Pathways
    Glycosaminoglycan Metabolic Process
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