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GFAP anticorps (C-Term)

GFAP Reactivité: Humain, Rat, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044350
  • Antigène Voir toutes GFAP Anticorps
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    Épitope
    • 30
    • 27
    • 21
    • 17
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    • 9
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    • 1
    • 1
    • 1
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    AA 417-432, C-Term
    Reactivité
    • 298
    • 177
    • 170
    • 54
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    • 37
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    • 13
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    • 11
    • 11
    • 6
    • 5
    • 3
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    • 1
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    Humain, Rat, Souris
    Hôte
    • 194
    • 144
    • 12
    • 3
    • 2
    • 1
    Lapin
    Clonalité
    • 195
    • 161
    Polyclonal
    Conjugué
    • 167
    • 29
    • 25
    • 19
    • 13
    • 9
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    Cet anticorp GFAP est non-conjugé
    Application
    • 288
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    • 87
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    • 30
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Glial fibrillary acidic protein(GFAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    DGEVIKESKQ EHKDVM
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Glial fibrillary acidic protein(GFAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: glial fibrillary acidic protein
    Protein Name: Glial fibrillary acidic protein(GFAP)
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human GFAP(417-432aa DGEVIKESKQEHKDVM), identical to the related rat sequence, and different from the related mouse sequence by two amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product GFAP Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Popov, Brazhe, Fedotova, Tiaglik, Bychkov, Morozova, Brazhe, Aronov, Lyukmanova, Lazareva, Li, Ponimaskin, Verkhratsky, Semyanov: "A high-fat diet changes astrocytic metabolism to promote synaptic plasticity and behavior." dans: Acta physiologica (Oxford, England), pp. e13847, (2022) (PubMed).

    Liu, Mei, Li, Roboti, Pang, Ying, Gao, Lowe, Bao: "Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 2, pp. 346-351, (2018) (PubMed).

    Xu, Hu, Jiang, Pan, Shen, Schachner: "Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice." dans: Disease models & mechanisms, Vol. 10, Issue 9, pp. 1117-1128, (2018) (PubMed).

    Liu, Zhao, Ji, Zhu, Sui, Knight, Burnstock, He, Yuan, Xiang: "Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats." dans: Purinergic signalling, Vol. 13, Issue 4, pp. 529-544, (2018) (PubMed).

    Zhou, Wang, Li, Wang, Wu, Zhang: "Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury." dans: Molecular medicine reports, Vol. 15, Issue 5, pp. 3179-3185, (2017) (PubMed).

    Daugherty, Chechneva, Mayrhofer, Deng: "The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis." dans: Scientific reports, Vol. 6, pp. 22556, (2017) (PubMed).

    Mi, Gao, Liu, Ye, Li, Jin, Yang, Yang: "Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model." dans: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 20, pp. 2780-91, (2017) (PubMed).

    Zhai, Zhao, Zhou, Lu, Zhang, Na, Feng, Qiang, Du: "The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects." dans: Nutrition journal, Vol. 15, Issue 1, pp. 95, (2017) (PubMed).

    Yang, Xie, Hu, Jiang, Shen, Schachner, Zhao: "CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells." dans: Frontiers in molecular neuroscience, Vol. 10, pp. 324, (2017) (PubMed).

    Jiang, Luo, Qin, Ma, Li, Zhan, Zhang: "Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats." dans: Frontiers in molecular neuroscience, Vol. 10, pp. 363, (2017) (PubMed).

    Tang, Luo, Qiu, Zhang, Lu, Huang, Xu, Xu: "Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy." dans: Scientific reports, Vol. 7, Issue 1, pp. 18110, (2017) (PubMed).

    Yuan, Hu, Gao: "Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats." dans: PLoS ONE, Vol. 10, Issue 8, pp. e0134722, (2016) (PubMed).

    Cui, Li, Gai, She, Zhang, Xu, Chen, An, Ma, Wang: "Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer's Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus." dans: Scientific reports, Vol. 5, pp. 12943, (2016) (PubMed).

    Liao, Jiang, Wang, Zhao, Chen, Li, Wang, Jie, Zhou, Zhang, Chen, Hu: "Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration." dans: Scientific reports, Vol. 5, pp. 15356, (2016) (PubMed).

    Zhu, Li, Luo, Wang, Li, Xie, Gao, Song, Su, Liang et al.: "Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related ..." dans: Journal of translational medicine, Vol. 13, pp. 356, (2016) (PubMed).

    Hu, Zhang, Tian, Xun, Wang, Lv: "Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro." dans: Molecular medicine reports, Vol. 13, Issue 1, pp. 49-58, (2016) (PubMed).

    Xiao, Zhang, Zhang, Wang, Chen, Chen, Lv, Shi, Dong: "Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c." dans: International journal of molecular medicine, Vol. 37, Issue 3, pp. 716-26, (2016) (PubMed).

    Yang, Li, Li, Feng, Liu, Han, Zhang, Qin, Zhang, Nie, Jin: "Effect of Corilagin on the Proliferation and NF-κB in U251 Glioblastoma Cells and U251 Glioblastoma Stem-Like Cells." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 1418309, (2016) (PubMed).

    Zeng, Zhao, Ouyang, Zhao, Zhang, Chen, Yu, Lei: "Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cultivated in serum-free medium." dans: Oncology letters, Vol. 12, Issue 2, pp. 815-824, (2016) (PubMed).

    Mbori, Chuan, Feng, Alizada, Zhan: "Evaluation of the Combination of Methylprednisolone and Tranilast after Spinal Cord Injury in Rat Models." dans: Journal of Korean Neurosurgical Society, Vol. 59, Issue 4, pp. 334-40, (2016) (PubMed).

  • Antigène
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    Autre désignation
    GFAP (GFAP Produits)
    Synonymes
    anticorps GFAP, anticorps AI836096, anticorps cb345, anticorps etID36982.3, anticorps gfapl, anticorps wu:fb34h11, anticorps wu:fk42c12, anticorps xx:af506734, anticorps zgc:110485, anticorps glial fibrillary acidic protein, anticorps GFAP, anticorps LOC100136168, anticorps gfap, anticorps Gfap
    Sujet
    Glial fibrillary acidic protein(GFAP) is an intermediate-filament(IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.

    Synonyms: Astrocyte antibody|FLJ42474 antibody|FLJ45472 antibody|GFAP antibody|GFAP_HUMAN antibody|Glial Fibrillary Acidic Protein antibody|Intermediate filament protein antibody
    UniProt
    P14136
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