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Cyclin D1 anticorps (C-Term)

CCND1 Reactivité: Humain, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044355
  • Antigène Voir toutes Cyclin D1 (CCND1) Anticorps
    Cyclin D1 (CCND1)
    Épitope
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    AA 219-238, C-Term
    Reactivité
    • 246
    • 131
    • 125
    • 38
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    • 10
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    • 4
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    • 1
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    Humain, Rat
    Hôte
    • 211
    • 59
    • 1
    Lapin
    Clonalité
    • 199
    • 70
    Polyclonal
    Conjugué
    • 122
    • 29
    • 21
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    Cet anticorp Cyclin D1 est non-conjugé
    Application
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    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Mouse,Rat.
    Séquence
    SPNNFLSCYR TTHFLSRVIK
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: cyclin D1
    Protein Name: G1/S-specific cyclin-D1
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cyclin D1(219-238aa SPNNFLSCYRTTHFLSRVIK), identical to the related rat sequence, and different from the related human sequence by three amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CCND1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Yang, Gao, Ma, Teng, Liu, Wei, Lu, Cheng, Hou, Zou: "Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells." dans: Oncotarget, Vol. 7, Issue 25, pp. 38025-38035, (2018) (PubMed).

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    Li, Zheng, Ji, Liu, Lv, Yang, Hu, Chen, Zhang, Cao: "Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: A preclinical study." dans: Oncology reports, Vol. 39, Issue 4, pp. 1609-1618, (2018) (PubMed).

    Li, Wang, Zhou, Shuang, Zhao, Chen: "Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 2384-2390, (2018) (PubMed).

    Xiao, Dong, Cheng, Mao, Zong, Wu, Wang, Xie, Wang, Lei, Guo: "LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling." dans: International journal of oncology, Vol. 53, Issue 3, pp. 1069-1082, (2018) (PubMed).

    Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." dans: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).

    Ji, Liu, Zhao, Guo, Xia, Lu, Yin, Xu: "Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3‑E1 cells." dans: Molecular medicine reports, Vol. 16, Issue 5, pp. 7391-7397, (2017) (PubMed).

    Yuan, Zheng, Li, Xiang, Gao, Ran, Sun, Huang, Xie, Du, Xiao: "Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2." dans: Acta biochimica et biophysica Sinica, Vol. 48, Issue 3, pp. 220-8, (2016) (PubMed).

    Xu, Gu, Ni, Li, Yu, Li, Liu: "The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and their clinicopathological significance." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 11, pp. 21222-8, (2016) (PubMed).

    Wang, Wang, Xiong, Chen, Ma, Cai, Gao, Sun, Yang, Pang: "Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a." dans: Scientific reports, Vol. 6, pp. 21865, (2016) (PubMed).

    Fan, Li, Li, Wang, Du, Yang, Zhao, Li: "Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells." dans: OncoTargets and therapy, Vol. 9, pp. 2795-803, (2016) (PubMed).

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    He, Chen, Wang, Zhao, Wan, Wang, Mo: "miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/?-catenin signaling." dans: International journal of molecular medicine, Vol. 35, Issue 6, pp. 1587-95, (2015) (PubMed).

    Li, Gao, Chu, Teng, Lv, Yang, Yin: "The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo." dans: European journal of pharmacology, Vol. 749, pp. 107-14, (2015) (PubMed).

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    Zhang, Hu, Liu, Ye, Gui, Zhou, Qi, He, Wang, Wang: "CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment." dans: Scientific reports, Vol. 5, pp. 15948, (2015) (PubMed).

    Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." dans: Carcinogenesis, Vol. 35, Issue 8, pp. 1901-10, (2014) (PubMed).

    Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." dans: BMC cancer, Vol. 14, pp. 686, (2014) (PubMed).

    Zhang, Zhao, Huang, Meng, Bian, Li: "Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar carcinoma HepG2 cells." dans: PLoS ONE, Vol. 9, Issue 5, pp. e95520, (2014) (PubMed).

    Liu, Zhu, Xiong, Zheng, Hu, Qiu: "Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells." dans: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5750-61, (2014) (PubMed).

  • Antigène
    Cyclin D1 (CCND1)
    Autre désignation
    CCND1 (CCND1 Produits)
    Synonymes
    anticorps BCL1, anticorps D11S287E, anticorps PRAD1, anticorps U21B31, anticorps AI327039, anticorps CycD1, anticorps Cyl-1, anticorps bcl-1, anticorps cD1, anticorps cb161, anticorps cycd1, anticorps etID37810.7, anticorps fb52e01, anticorps fc45c08, anticorps fc83a12, anticorps id:ibd1198, anticorps wu:fb52e01, anticorps wu:fc45c08, anticorps wu:fc83a12, anticorps ccnd1b, anticorps prad1, anticorps ccnd1, anticorps ccnd1a, anticorps bcl1, anticorps d11s287e, anticorps u21b31, anticorps CCND1, anticorps cyclin D1, anticorps cyclin D1 S homeolog, anticorps cyclin D1 L homeolog, anticorps CCND1, anticorps Ccnd1, anticorps ccnd1, anticorps ccnd1.S, anticorps ccnd1.L
    Sujet
    Cyclin D1, also known as CCND1, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al.(2003) found that prolactin(PRL, 176760) induced IGF2(147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

    Synonyms: AI327039 antibody|B cell ccl/lymphoma 1 antibody|B cell CLL/lymphoma 1 antibody|B cell leukemia 1 antibody|B-cell leukemia 1 antibody|B cell lymphoma 1 protein antibody|B-cell lymphoma 1 protein antibody|BCL 1 antibody|BCL-1 antibody|BCL-1 oncogene antibody|BCL1 antibody|BCL1 oncogene antibody|CCND 1 antibody|CCND1 antibody|CCND1 protein antibody|CCND1/FSTL3 fusion gene, included antibody|CCND1/IGHG1 fusion gene antibody|CCND1/IGHG1 fusion gene, included antibody|CCND1/IGLC1 fusion gene, included antibody|CCND1/PTH fusion gene, included antibody|CCND1_HUMAN antibody|cD1 antibody|Cyl 1 antibody|D11S287E antibody|G1/S specific cyclin D1 antibody|G1/S-specific cyclin-D1 antibody|Parathyroid adenomatosis 1 antibody|PRAD1 antibody|PRAD1 oncogene antibody|U21B31 antibody
    UniProt
    P25322
    Pathways
    Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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