XIAP anticorps (N-Term)

N° du produit ABIN3044425

Détail du produit anti-XIAP anticorps

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Épitope: AA 14-34, N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XIAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase XIAP(XIAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: ADINKEEEFV EEFNRLKTFA N

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase XIAP(XIAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: X-linked inhibitor of apoptosis
Protein Name: E3 ubiquitin-protein ligase XIAP

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human XIAP(14-34aa ADINKEEEFVEEFNRLKTFAN), different from the related mouse sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-XIAP (ABIN3044425)

Wei, Gao, Zheng, Zhang, Liu, Yang, Teng, Hou, Yin, Zou: "Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice." dans: Marine drugs, Vol. 15, Issue 3, (2017) (PubMed).

Chen, Mao, Qiu, Liu: "Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage." dans: Neural regeneration research, Vol. 10, Issue 3, pp. 425-31, (2015) (PubMed).

Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: "Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1." dans: Biochemical and biophysical research communications, Vol. 434, Issue 4, pp. 809-14, (2013) (PubMed).

Wu, Xi, Guo, Liu, Yang, Liu, Dong, Guo: "Exogenous ARC down-regulates caspase-3 expression and inhibits apoptosis of broiler chicken cardiomyocytes exposed to hydrogen peroxide." dans: Avian pathology : journal of the W.V.P.A, Vol. 42, Issue 1, pp. 32-7, (2013) (PubMed).

Détails sur XIAP

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Autre désignation: XIAP (XIAP Produits)

Synonymes: anticorps API3, anticorps BIRC4, anticorps IAP-3, anticorps ILP1, anticorps MIHA, anticorps XLP2, anticorps hIAP-3, anticorps hIAP3, anticorps api3, anticorps birc4, anticorps ilp1, anticorps miha, anticorps xlp2, anticorps xxiap, anticorps 1110015C02Rik, anticorps Aipa, anticorps Api3, anticorps Birc4, anticorps IAP3, anticorps ILP-1, anticorps mXIAP, anticorps riap3, anticorps fb73d01, anticorps wu:fb73d01, anticorps zgc:91873, anticorps BIRC8, anticorps X-linked inhibitor of apoptosis, anticorps X-linked inhibitor of apoptosis L homeolog, anticorps XIAP, anticorps xiap, anticorps xiap.L, anticorps Xiap

Sujet: BIRC4, baculoviral IAP repeat-containing protein 4 is also known as XIAP(X-linked inhibitor of apoptosis protein). The BIRC4 gene comprises 6 exons. This gene is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Synonyms: AP 13 antibody|API3 antibody|Apoptosis Inhibitor 3 antibody|Baculoviral IAP repeat containing 4 antibody|Baculoviral IAP Repeat Containing Protein 4 antibody|Baculoviral IAP repeat-containing protein 4 antibody|BIRC 4 antibody|BIRC4 antibody|E3 ubiquitin-protein ligase XIAP antibody|hIAP-3 antibody|hIAP3 antibody|HILP antibody|IAP 3 antibody|IAP like protein antibody|IAP-3 antibody|IAP-like protein antibody|IAP3 antibody|ILP 1 antibody|ILP antibody|ILP1 antibody|Inhibitor of apoptosis protein 3 antibody|Inhibitor of Apoptosis X Linked antibody|Mammalian IAP Homologue A antibody|MIHA antibody|X linked IAP antibody|X linked inhibitor of apoptosis antibody|X linked inhibitor of apoptosis protein antibody|X-linked IAP antibody|X-linked inhibitor of apoptosis protein antibody|Xiap antibody|XIAP_HUMAN antibody|XLP2 antibody

UniProt: P98170

Pathways: Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis