RUVBL1 anticorps (N-Term)

N° du produit ABIN309654

Détail du produit anti-RUVBL1 anticorps

Antigène: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUVBL1 est non-conjugé

Application: Western Blotting (WB)

Séquence: KIEEVKSTTK TQRIASHSHV KGLGLDESGL AKQAASGLVG QENAREACGV

Homologie: Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 456 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RUVBL1

Antigène: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Autre désignation: RUVBL1 (RUVBL1 Produits)

Synonymes: anticorps rvb1, anticorps ecp54, anticorps tip49, anticorps nmp238, anticorps pontin, anticorps tip49a, anticorps xpontin, anticorps pontin52, anticorps TIP49, anticorps wu:fd18e04, anticorps zpontin, anticorps ECP54, anticorps INO80H, anticorps NMP238, anticorps PONTIN, anticorps Pontin52, anticorps RVB1, anticorps TIH1, anticorps TIP49A, anticorps Tip49a, anticorps 2510009G06Rik, anticorps RuvB like AAA ATPase 1, anticorps RuvB-like 1 (E. coli), anticorps RuvB-like 1, anticorps RuvB like AAA ATPase 1 S homeolog, anticorps RuvB-like AAA ATPase 1, anticorps RuvB-like protein 1, anticorps RUVBL1, anticorps ruvbl1, anticorps PVX_123295, anticorps Bm1_15605, anticorps ruvb1, anticorps ruvbl1.S, anticorps Ruvbl1

Sujet: RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Alias Symbols: ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
Protein Interaction Partner: RUVBL2, HUWE1, CEP250, RPAP3, UBC, NEDD8, SUMO1, RNF2, EED, rev, NEDD4, CDC42, IQGAP1, PARK2, FBXO6, USP49, FBXO46, FBXW4, RBM8A, TELO2, TTI1, URI1, RUVBL1, TRRAP, TUBA1A, TUBB, SMG9, UPF1, PRKDC, POLR2E, NCBP1, LMNA, HSPA4, SMG8, PIH1D1, PABPC1, SMG1, PA
Protein Size: 456

Poids moléculaire: 50 kDa

ID gène: 8607

NCBI Accession: NM_003707, NP_003698

UniProt: Q9Y265

Pathways: Telomere Maintenance