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SF3B1 anticorps (N-Term)

SF3B1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Chévre, Lapin, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN310007
  • Antigène Voir toutes SF3B1 Anticorps
    SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
    Épitope
    • 15
    • 10
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 59
    • 40
    • 34
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Chévre, Lapin, Poisson zèbre (Danio rerio)
    Hôte
    • 70
    • 4
    Lapin
    Clonalité
    • 58
    • 16
    Polyclonal
    Conjugué
    • 33
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SF3B1 est non-conjugé
    Application
    • 54
    • 24
    • 24
    • 13
    • 13
    • 12
    • 9
    • 6
    • 4
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR
    Homologie
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against SF3B1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human SF3B1
    Top Product
    Discover our top product SF3B1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 1304 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
    Autre désignation
    SF3B1 (SF3B1 Produits)
    Synonymes
    anticorps Cus1, anticorps SAP145, anticorps SF3B145, anticorps SF3b1, anticorps SF3b150, anticorps Hsh155, anticorps MDS, anticorps PRP10, anticorps PRPF10, anticorps SAP155, anticorps SF3b155, anticorps 155kDa, anticorps 2810001M05Rik, anticorps AA409119, anticorps Prp10, anticorps TA-8, anticorps Targ4, anticorps hsh155, anticorps prp10, anticorps prpf10, anticorps sap155, anticorps SF3B1, anticorps Sap155, anticorps wu:fb99f09, anticorps splicing factor 3b subunit 2, anticorps splicing factor 3b subunit 1, anticorps splicing factor 3b, subunit 1, anticorps splicing factor 3b subunit 1 S homeolog, anticorps SF3B2, anticorps SF3B1, anticorps Sf3b1, anticorps sf3b1.S, anticorps sf3b1
    Sujet
    SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Alias Symbols: PRP10, SAP155, SF3b155, MDS, Hsh155, PRPF10
    Protein Interaction Partner: SART3, SUMO2, SUMO3, MDM2, STAU1, UBC, LGR4, WWOX, RPA3, RPA2, RPA1, ERG, EED, RNF2, EZH2, SUZ12, APBB1, PRPF40A, WBP4, TCERG1, FBXO6, RBM17, SNIP1, SF3B6, WHSC1, RPS2, RPL23A, RPL18A, RPL10, RPL3, PLRG1, SMAD9, SMAD5, SMAD1, IL7R, FN1, ESR1, CSNK2A1, EIF
    Protein Size: 1304
    Poids moléculaire
    143 kDa
    ID gène
    23451
    NCBI Accession
    NM_012433, NP_036565
    UniProt
    O75533
    Pathways
    Chromatin Binding
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