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SF3A1 anticorps (N-Term)

SF3A1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio) WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN310053
  • Antigène Voir toutes SF3A1 Anticorps
    SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 24
    • 13
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)
    Hôte
    • 18
    • 6
    Lapin
    Clonalité
    • 19
    • 5
    Polyclonal
    Conjugué
    • 24
    Cet anticorp SF3A1 est non-conjugé
    Application
    • 23
    • 11
    • 9
    • 8
    • 7
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    QQTTQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against SF3A1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human SF3A1
    Top Product
    Discover our top product SF3A1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 793 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

  • Antigène
    SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))
    Autre désignation
    SF3A1 (SF3A1 Produits)
    Synonymes
    anticorps Dmel\\CG16941, anticorps SF3a1, anticorps SF3a120, anticorps DDBDRAFT_0168938, anticorps DDBDRAFT_0233180, anticorps DDB_0168938, anticorps DDB_0233180, anticorps 1200014H24Rik, anticorps 5930416L09Rik, anticorps AI159724, anticorps si:dz150f13.2, anticorps wu:fc38e01, anticorps wu:fc50a11, anticorps wu:fj37c05, anticorps zgc:65786, anticorps PRP21, anticorps PRPF21, anticorps SAP114, anticorps SF3A120, anticorps CG16941 gene product from transcript CG16941-RA, anticorps SWAP/Surp domain-containing protein, anticorps splicing factor 3a, subunit 1, anticorps splicing factor 3a subunit 1, anticorps CG16941, anticorps sf3a1, anticorps spl1, anticorps Sf3a1, anticorps SF3A1
    Sujet
    SF3A1 is the subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Alias Symbols: PRP21, PRPF21, SAP114, SF3A120
    Protein Interaction Partner: HDAC1, FUS, HUWE1, UBC, RPA3, RPA2, RPA1, WWOX, ZBTB1, SUZ12, EED, RNF2, rev, NR3C1, APBB1, HNRNPR, GAS7, CCDC6, PPP4R2, BRCC3, SMEK1, PRPF40A, GAPVD1, WBP4, TCERG1, HDAC11, HDAC6, SF3A3, DDX42, RBM10, SF3A2, SF1, WHSC1, IL7R, CSNK2A1, WDR77, RBFOX2, SMUR
    Protein Size: 793
    Poids moléculaire
    89 kDa
    ID gène
    10291
    NCBI Accession
    NM_005877, NP_005868
    UniProt
    Q15459
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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