ALAD anticorps (N-Term)

N° du produit ABIN310191

Détail du produit anti-ALAD anticorps

Antigène: ALAD (Aminolevulinate Dehydratase (ALAD))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALAD est non-conjugé

Application: Western Blotting (WB)

Séquence: EEMLRPLVEE GLRCVLIFGV PSRVPKDERG SAADSEESPA IEAIHLLRKT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ALAD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ALAD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 359 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ALAD (ABIN310191)

Tang, Breinig, Stith, Mischel, Tannir, Kokona, Fairman, Jaffe: "Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins)." dans: The Journal of biological chemistry, Vol. 281, Issue 10, pp. 6682-90, (2006) (PubMed).

Détails sur ALAD

Antigène: ALAD (Aminolevulinate Dehydratase (ALAD))

Autre désignation: ALAD (ALAD Produits)

Synonymes: anticorps DDBDRAFT_0190269, anticorps DDBDRAFT_0231415, anticorps DDB_0190269, anticorps DDB_0231415, anticorps ALAD, anticorps ncf, anticorps ALADH, anticorps PBGS, anticorps ALADR, anticorps aminolevulinatedelta-dehydratase, anticorps zgc:110219, anticorps Lv, anticorps delta-aminolevulinate dehydratase, anticorps aminolevulinate dehydratase, anticorps delta-aminolevulinic acid dehydratase, anticorps Delta-aminolevulinic acid dehydratase, anticorps aminolevulinate dehydratase L homeolog, anticorps aminolevulinate, delta-, dehydratase, anticorps hemB, anticorps ALAD, anticorps PBGS, anticorps STY0404, anticorps SAS1597, anticorps SACI_RS03725, anticorps PAAG_00299, anticorps VDBG_00315, anticorps HPPC_00830, anticorps MGYG_01952, anticorps hem2, anticorps alad.L, anticorps Alad, anticorps alad

Sujet: The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 Molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway, zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 Molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway, zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: ALADH, MGC5057, PBGS
Protein Interaction Partner: C14orf142, P3H1, RPRD1B, PPME1, LAP3, DBNL, HSPBP1, GPN1, WDR4, ACTR2, TOM1L1, ZPR1, OGT, SURF2, LPP, AGFG1, UBD, UBC, ALAD,
Protein Size: 359

Poids moléculaire: 39 kDa

ID gène: 210

NCBI Accession: NM_001003945, NP_001003945

UniProt: Q6ZMU0