SLC19A1 anticorps (N-Term)

N° du produit ABIN310565

Détail du produit anti-SLC19A1 anticorps

Antigène: SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC19A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SLC19A1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC19A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 591 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SLC19A1 (ABIN310565)

Halwachs, Lakoma, Schäfer, Seibel, Honscha: "The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier." dans: Molecular pharmacology, Vol. 80, Issue 4, pp. 621-9, (2011) (PubMed).

Marchi, Paoluzzi, Scotto, Seshan, Zain, Zinzani, OConnor: "Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 14, pp. 3648-58, (2010) (PubMed).

Détails sur SLC19A1

Antigène: SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1))

Autre désignation: SLC19A1 (SLC19A1 Produits)

Synonymes: anticorps A1, anticorps MHCBFB, anticorps PO-GA, anticorps RECC1, anticorps RFC, anticorps RFC140, anticorps CHMD, anticorps FOLT, anticorps IFC1, anticorps REFC, anticorps RFC1, anticorps LOC100226745, anticorps AI323572, anticorps RFC-1, anticorps MTX1, anticorps XRFC, anticorps chmd, anticorps folt, anticorps ifc1, anticorps refc, anticorps rfc1, anticorps slc19a1, anticorps replication factor C subunit 1, anticorps solute carrier family 19 member 1, anticorps folate transporter 1, anticorps solute carrier family 19 (folate transporter), member 1, anticorps solute carrier family 19 (folate transporter), member 1 L homeolog, anticorps RFC1, anticorps SLC19A1, anticorps LOC100226745, anticorps Slc19a1, anticorps slc19a1.L

Sujet: Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. SLC19A1 plays a role in maintaining intracellular concentrations of folate.Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM].
Alias Symbols: CHMD, FOLT, IFC1, REFC, RFC1
Protein Interaction Partner: UBC,
Protein Size: 591

Poids moléculaire: 65 kDa

ID gène: 6573

NCBI Accession: NM_194255, NP_919231

UniProt: P41440

Pathways: Dicarboxylic Acid Transport