SEMA6D anticorps (N-Term)

N° du produit ABIN311204

Détail du produit anti-SEMA6D anticorps

Antigène: SEMA6D (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6D (SEMA6D))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SEMA6D est non-conjugé

Application: Western Blotting (WB)

Séquence: VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ LMLKIRDTLY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SEMA6D. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SEMA6D

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 476 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SEMA6D (ABIN311204)

Toyofuku, Zhang, Kumanogoh, Takegahara, Suto, Kamei, Aoki, Yabuki, Hori, Fujisawa, Kikutani: "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2." dans: Genes & development, Vol. 18, Issue 4, pp. 435-47, (2004) (PubMed).

Détails sur SEMA6D

Antigène: SEMA6D (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6D (SEMA6D))

Autre désignation: SEMA6D (SEMA6D Produits)

Synonymes: anticorps 1110067B02Rik, anticorps AA409156, anticorps D330011G23, anticorps Sema6D-1, anticorps Sema6D-2, anticorps Sema6D-4, anticorps Sema6D-5, anticorps Sema6D-6, anticorps mKIAA1479, anticorps wu:fi06a12, anticorps wu:fi76a10, anticorps zgc:56170, anticorps semaphorin 6D, anticorps sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, anticorps semaphorin 6D L homeolog, anticorps SEMA6D, anticorps Sema6d, anticorps sema6d, anticorps sema6d.L

Sujet: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphoring domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. SEMA6D is a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
Alias Symbols: FLJ11598, KIAA1479
Protein Interaction Partner: PLXNA1,
Protein Size: 476

Poids moléculaire: 52 kDa

ID gène: 80031

NCBI Accession: NM_024966, NP_079242

UniProt: Q8NFY4

Pathways: Smooth Muscle Cell Migration