CHN2 anticorps (N-Term)

N° du produit ABIN311468

Détail du produit anti-CHN2 anticorps

Antigène: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHN2 est non-conjugé

Application: Western Blotting (WB)

Séquence: AFGVKVGVKG GFLWPPLKLF ACSQISSLVR RAALTHNDNH FNYEKTHNFK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CHN2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CHN2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 332 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CHN2

Antigène: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Autre désignation: CHN2 (CHN2 Produits)

Synonymes: anticorps 1700026N20Rik, anticorps 4930557O16Rik, anticorps ARHGAP3, anticorps Bch, anticorps BCH, anticorps CHN2-3, anticorps RHOGAP3, anticorps chimerin 2, anticorps chimerin 2 L homeolog, anticorps chn2, anticorps CHN2, anticorps Chn2, anticorps chn2.L

Sujet: CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: ARHGAP3, BCH, MGC138360, RHOGAP3, CHN2-3
Protein Interaction Partner: ERBB3, RAC1, RACGAP1, TGFBR1, BAG6, AKT1,
Protein Size: 332

Poids moléculaire: 38 kDa

ID gène: 1124

NCBI Accession: NM_001039936, NP_001035025

UniProt: P52757