BIK anticorps (N-Term)

N° du produit ABIN318742

Détail du produit anti-BIK anticorps

Antigène: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIK est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects an epitope within the N-terminal (NT) region of Bcl-2-interacting killer (Bik) also known as natural born killer (Nbk).

Purification: Purified

Immunogène: 15 amino acid peptide from near the amino terminus of human Bik.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 - 2g/mL, detects a band of approximately 18 kDa in Jurkat cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BIK

Antigène: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Autre désignation: BIK (BIK Produits)

Synonymes: anticorps BIK, anticorps Biklk, anticorps Blk, anticorps Nbk, anticorps BIP1, anticorps BP4, anticorps NBK, anticorps si:dkey-31f5.6, anticorps BCL2 interacting killer, anticorps BCL2-interacting killer, anticorps BCL2-interacting killer (apoptosis-inducing), anticorps BIK, anticorps Bik, anticorps bik

Sujet: Bik is a Bcl-2 homology domain 3 (BH3)-only protein of 18kD which requires the BAX gene for activation. Bik forms heterodimers with various antiapoptotic proteins such as Bcl-2 and Bcl-XL, inhibiting their antiapoptotic function. This can result in the release of Ca2+ and cytochrome C into the cytosol, leading to apoptosis. Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumour suppressor gene.Synonyms: Apoptosis inducer NBK, BIP1, BP4, Bcl-2-interacting killer, NBK

ID gène: 638

NCBI Accession: NP_001188

UniProt: Q13323

Pathways: Positive Regulation of Endopeptidase Activity