ORAI3 anticorps (N-Term)

N° du produit ABIN318923

Détail du produit anti-ORAI3 anticorps

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. This antibody is not expected to cross react with either ORAI1 or ORAI2.

Purification: Purified

Immunogène: A 15 amino acid peptide from near the amino terminus of human ORAI3.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on frozen sections: 10g/mL. Western Blot: 1 - 2g/mL, detects a band of approximately 35 kDa in A20 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C

Stockage commentaire: Store at +4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted.

Détails sur ORAI3

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Autre désignation: ORAI3 (ORAI3 Produits)

Synonymes: anticorps ORAI3, anticorps TMEM142C, anticorps 9930124N15, anticorps BC061259, anticorps Tmem142c, anticorps RGD1306538, anticorps ORAI calcium release-activated calcium modulator 3, anticorps ORAI3, anticorps Orai3

Sujet: Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C

ID gène: 93129

NCBI Accession: NP_689501

UniProt: Q9BRQ5