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CBL anticorps (pTyr700)

CBL Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN319293
  • Antigène Voir toutes CBL Anticorps
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Épitope
    • 30
    • 29
    • 28
    • 17
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr700
    Reactivité
    • 179
    • 80
    • 71
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 152
    • 25
    • 3
    • 1
    Lapin
    Clonalité
    • 143
    • 38
    Polyclonal
    Conjugué
    • 80
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Cet anticorp CBL est non-conjugé
    Application
    • 85
    • 52
    • 52
    • 49
    • 34
    • 27
    • 21
    • 17
    • 12
    • 11
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This Antibody detects endogenous levels of c-Cbl only when phosphorylated at Tyrosine 770.
    Purification
    Affinity Chromatography
    Immunogène
    Synthetic phosphopeptide derived from human c-Cbl around the phosphorylation site of Tyrosine 770 (T-E-YP-M-T).
    Top Product
    Discover our top product CBL Anticorps primaire
  • Indications d'application
    Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at-20 °C.
  • Antigène
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Autre désignation
    CBL / RNF55 (CBL Produits)
    Synonymes
    anticorps 4732447J05Rik, anticorps Cbl-2, anticorps c-Cbl, anticorps cbl, anticorps C-CBL, anticorps CBL2, anticorps FRA11B, anticorps NSLL, anticorps RNF55, anticorps c-cbl-like, anticorps RGD1561386, anticorps Casitas B-lineage lymphoma, anticorps Cbl proto-oncogene, anticorps Cbl, anticorps CBL
    Sujet
    The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL's interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
    ID gène
    867
    NCBI Accession
    NP_005179
    UniProt
    P22681
    Pathways
    TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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