CD56 anticorps

N° du produit ABIN319784

Détail du produit anti-CD56 anticorps

Antigène: CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD56 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: This antibody recognises N-CAM expressed on developing and adult neuroectodermal tissues. Neuroectodermal tumours also stain including Glioma, ependymoma, neuroblastoma, medulloblastoma, retinoblastoma and teratoma. Oat cell carcinoma and Wilms tumour are also highly reactive. Will react on Natural Killer cells. Recognises 140, 180 and 120 kDa NCAM isoforms.

Purification: Affinity Chromatography on Protein A.

Immunogène: Spleen cells from immunised BALB/c mice were fused with cells of the P3/X63.Ag8 mouse myeloma line.

Clone: ERIC-1

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 80 ng/mL. Immunoblotting. Immunohistochemistry on Frozen Sections (1/50-1/100). Recommended Positive Control: Neuroblastoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD56

Antigène: CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))

Autre désignation: CD56 (NCAM1 Produits)

Synonymes: anticorps CD56, anticorps MSK39, anticorps NCAM, anticorps fj56g09, anticorps ncam, anticorps ncam1, anticorps wu:fj56g09, anticorps NCAM1, anticorps n-cam, anticorps E-NCAM, anticorps NCAM-1, anticorps Ncam, anticorps Cd56, anticorps N-CAM, anticorps N-CAM-1, anticorps NCAM-C, anticorps NCAMC, anticorps N-CAM-1-B, anticorps NCAM-1-B, anticorps ncam1-a, anticorps ncam1-b, anticorps neural cell adhesion molecule 1, anticorps neural cell adhesion molecule 1a, anticorps neural cell adhesion molecule 1 S homeolog, anticorps neural cell adhesion molecule 1 L homeolog, anticorps NCAM1, anticorps ncam1a, anticorps ncam1, anticorps LOC100085373, anticorps ncam1.S, anticorps Ncam1, anticorps ncam1.L

Sujet: NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.Synonyms: N-CAM-1, NCAM, NCAM-1, Neural cell adhesion molecule 1

ID gène: 4684

NCBI Accession: NP_000606

UniProt: P13591