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CACNA1C anticorps (AA 50-100)

CACNA1C Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN350137
  • Antigène Voir toutes CACNA1C Anticorps
    CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
    Épitope
    • 12
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-100
    Reactivité
    • 33
    • 21
    • 21
    • 15
    • 1
    • 1
    Humain
    Hôte
    • 28
    • 16
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 32
    • 15
    Polyclonal
    Conjugué
    • 25
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CACNA1C est non-conjugé
    Application
    • 30
    • 23
    • 19
    • 17
    • 15
    • 13
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for CACNA1C.
     Réactivité croisée
    Humain, Souris, Rat
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from AA 50-100 of human CACNA1C conjugated to blue carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence.
    Isotype
    IgG
    Top Product
    Discover our top product CACNA1C Anticorps primaire
  • Indications d'application
    IHC, WB (confirmed by recombinant protein). A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
    Autre désignation
    CACNA1C (CACNA1C Produits)
    Synonymes
    anticorps CACH2, anticorps CACN2, anticorps CACNL1A1, anticorps CCHL1A1, anticorps CaV1.2, anticorps LQT8, anticorps TS, anticorps Cav1.2, anticorps Cchl1a1, anticorps MBC, anticorps MELC-CC, anticorps RATIVS302, anticorps isl, anticorps C-LTCC, anticorps CHCACHA1C, anticorps ICA, anticorps cav1.2, anticorps ca(v)1.2, anticorps CAV1.2, anticorps BCR, anticorps rbc, anticorps calcium voltage-gated channel subunit alpha1 C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit, anticorps voltage-dependent L-type calcium channel subunit alpha-1C, anticorps calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog, anticorps Red blood cell count, anticorps RNA, 7SL, cytoplasmic 263, pseudogene, anticorps CACNA1C, anticorps Cacna1c, anticorps cacna1c, anticorps LOC100442085, anticorps cacna1c.S, anticorps RBC, anticorps RN7SL263P
    Sujet
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.,Alpha Subunit,CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C
    UniProt
    Q13936
    Pathways
    Hormone Transport, Carbohydrate Homeostasis
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