CACNA1I anticorps (Cytoplasmic Domain)

N° du produit ABIN350147

Détail du produit anti-CACNA1I anticorps

Antigène: CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))

Épitope: Cytoplasmic Domain

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA1I est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for CACNA1I.

Réactivité croisée: Humain, Souris, Rat

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from a cytoplasmic domain of human CACNA1I conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Isotype: IgG

Information d'application

Indications d'application: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur CACNA1I

Antigène: CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))

Autre désignation: CACNA1I (CACNA1I Produits)

Synonymes: anticorps CACNA1L, anticorps Ca(V)3.3, anticorps Cav3.3, anticorps ca(v)3.3, anticorps si:ch211-51h13.1, anticorps Ca(v)3.3, anticorps calcium voltage-gated channel subunit alpha1 I, anticorps voltage-dependent T-type calcium channel subunit alpha-1I, anticorps calcium channel, voltage-dependent, alpha 1I subunit, anticorps calcium channel, voltage-dependent, T type, alpha 1I subunit, anticorps CACNA1I, anticorps LOC100555412, anticorps Cacna1i, anticorps cacna1i

Sujet: Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Brain specific,Alpha Subunit,Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3

UniProt: Q9P0X4