CACNB2 anticorps (C-Term)

N° du produit ABIN350158

Détail du produit anti-CACNB2 anticorps

Antigène: CACNB2 (Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for CACNB2.

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from the c-terminal region of human CACNB2 (CAB2, MYSB) conjugated to an immunogenic carrier protein was used as the antigen.

Isotype: IgG

Information d'application

Indications d'application: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur CACNB2

Antigène: CACNB2 (Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2))

Autre désignation: CACNB2 (CACNB2 Produits)

Synonymes: anticorps CACNLB2, anticorps CAVB2, anticorps MYSB, anticorps AW060387, anticorps CAB2, anticorps Cavbeta2, anticorps Cchb2, anticorps Cacnlb2, anticorps Cacnb2, anticorps CACNB2, anticorps CACNB2.2, anticorps cacnb2a, anticorps im:7141271, anticorps si:dkey-32m20.2, anticorps calcium voltage-gated channel auxiliary subunit beta 2, anticorps calcium channel, voltage-dependent, beta 2 subunit, anticorps calcium channel, voltage-dependent, beta 2b, anticorps CACNB2, anticorps Cacnb2, anticorps cacnb2b

Sujet: Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4). BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Subcellular location: Cell membrane âÄ° sarcolemma, Peripheral membrane protein, Cytoplasmic side Tissue specificity: Expressed in all tissues.,Beta Subunit,Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNLB2

UniProt: Q08289

Pathways: Skeletal Muscle Fiber Development