GABARAP-L2 (AA 10-50) anticorps
Reactivité: Humain, Souris, Rat
IHC, WB
Hôte: Mouton
Polyclonal
unconjugated
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- Antigène
- GABARAP-L2
- Épitope
- AA 10-50
- Reactivité
- Humain, Souris, Rat
- Hôte
-
Mouton
- Clonalité
- Polyclonal
- Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificité
- Specific for GABARAPL2.
- Immunogène
- A synthetic peptide from aa region 10-50 of human GABA(A) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
- Isotype
- IgG
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- Indications d'application
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Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- Conseil sur la manipulation
- Avoid freeze and thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- GABARAP-L2
- Sujet
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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association withGOSR1.
Subcellular location: Golgi apparatus.
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Also known as: FLC3A, GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, General protein transport factor p16, MAP1 light chain 3-related protein.
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