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KCNJ1 anticorps (Cytoplasmic Domain)

KCNJ1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN350383
  • Antigène Voir toutes KCNJ1 Anticorps
    KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))
    Épitope
    • 19
    • 16
    • 8
    • 8
    • 6
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reactivité
    • 54
    • 25
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 69
    • 1
    • 1
    Lapin
    Clonalité
    • 71
    Polyclonal
    Conjugué
    • 21
    • 9
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp KCNJ1 est non-conjugé
    Application
    • 38
    • 26
    • 26
    • 25
    • 14
    • 9
    • 9
    • 8
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for KCNJ1.
     Réactivité croisée
    Humain
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from the cytoplasmic domain of human KCNJ1 (ROMK1, Kir1.1) conjugated to blue carrier protein was used as the antigen. The peptide is shares 92% identity with rat and mouse sequences.
    Isotype
    IgG
    Top Product
    Discover our top product KCNJ1 Anticorps primaire
  • Indications d'application
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))
    Autre désignation
    KCNJ1 (KCNJ1 Produits)
    Synonymes
    anticorps KIR1.1, anticorps ROMK, anticorps ROMK1, anticorps kir1.1, anticorps romk1, anticorps Kcnj, anticorps Kir1.1, anticorps Romk2, anticorps kcnj1, anticorps wu:fl37c05, anticorps zgc:63534, anticorps potassium voltage-gated channel subfamily J member 1, anticorps potassium voltage-gated channel subfamily J member 1 L homeolog, anticorps potassium inwardly-rectifying channel, subfamily J, member 1, anticorps potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1, anticorps KCNJ1, anticorps kcnj1.L, anticorps kcnj1, anticorps Kcnj1, anticorps kcnj1a.1
    Sujet
    FUNCTION: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Subcellular location: Membrane, Multi-pass membrane protein. Involvement in disease: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.,Inward Rectifier,ATP-sensitive inward rectifier potassium channel 1, Potassium channel, inwardly rectifying subfamily J member 1, ATP-regulated potassium channel ROM-K, Kir1.1, ROMK1
    UniProt
    P48048
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