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RUNX1 anticorps (AA 200-260)

RUNX1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN350817
  • Antigène Voir toutes RUNX1 Anticorps
    RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
    Épitope
    • 26
    • 16
    • 14
    • 13
    • 11
    • 11
    • 10
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 200-260
    Reactivité
    • 167
    • 104
    • 67
    • 13
    • 10
    • 10
    • 10
    • 9
    • 7
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 163
    • 16
    • 2
    • 1
    Lapin
    Clonalité
    • 164
    • 19
    Polyclonal
    Conjugué
    • 104
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RUNX1 est non-conjugé
    Application
    • 137
    • 80
    • 46
    • 37
    • 32
    • 23
    • 15
    • 13
    • 13
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for Runx1.
     Réactivité croisée
    Humain, Souris, Rat
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from AA 200-260 of human Runx1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
    Isotype
    IgG
    Top Product
    Discover our top product RUNX1 Anticorps primaire
  • Indications d'application
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
    Autre désignation
    Runx1 (RUNX1 Produits)
    Synonymes
    anticorps RUNX1, anticorps runx1, anticorps AI462102, anticorps AML1, anticorps Cbfa2, anticorps Pebp2a2, anticorps Pebpa2b, anticorps AML1-EVI-1, anticorps AMLCR1, anticorps CBFA2, anticorps EVI-1, anticorps PEBP2aB, anticorps runxa, anticorps Runx-1, anticorps XAML, anticorps Xaml1, anticorps aml, anticorps aml-1, anticorps aml1, anticorps aml1-evi-1, anticorps amlcr1, anticorps cbfa2, anticorps evi-1, anticorps pebp2ab, anticorps Aml1, anticorps uncharacterized LOC473981, anticorps runt-related transcription factor, anticorps runt related transcription factor 1, anticorps runt-related transcription factor 1, anticorps runt related transcription factor 1 L homeolog, anticorps LOC473981, anticorps runt, anticorps Runx1, anticorps RUNX1, anticorps runx1, anticorps runx1.L
    Sujet
    FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation. SUBUNIT: Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogate the transactivating and DNA-binding properties of RUNX1. TISSUE SPECIFICITY: Highest levels in thymus, bone marrow and peripheral blood.,Nuclear Signaling,Runt-related transcription factor 1, Core-binding factor, alpha 2 subunit, CBF-alpha 2, Acute myeloid leukemia 1 protein, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEBP2-alpha B, PEA2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, AML1, CBFA2
    UniProt
    Q01196
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