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STIM1 anticorps (Extracellular Domain)

STIM1 Reactivité: Humain, Rat, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN350881
  • Antigène Voir toutes STIM1 Anticorps
    STIM1 (Stromal Interaction Molecule 1 (STIM1))
    Épitope
    • 16
    • 15
    • 15
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-100, Extracellular Domain
    Reactivité
    • 76
    • 57
    • 27
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 79
    • 10
    • 1
    • 1
    Lapin
    Clonalité
    • 71
    • 20
    Polyclonal
    Conjugué
    • 43
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp STIM1 est non-conjugé
    Application
    • 47
    • 31
    • 26
    • 26
    • 25
    • 20
    • 12
    • 12
    • 9
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for STIM1.
    Immunogène
    A synthetic peptide from aa region 50-100 of extracellular domain of human STIM1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
    Isotype
    IgG
    Top Product
    Discover our top product STIM1 Anticorps primaire
  • Indications d'application
    A concentration of 10-50 µg/ml is recommended.
    The optimal concentration should be determined by the end user. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    STIM1 (Stromal Interaction Molecule 1 (STIM1))
    Autre désignation
    STIM1 (STIM1 Produits)
    Synonymes
    anticorps stim1, anticorps MGC76045, anticorps STIM1, anticorps si:dkey-24p1.5, anticorps MGC154748, anticorps si:ch211-112l17.2, anticorps Stim1, anticorps D11S4896E, anticorps GOK, anticorps TAM, anticorps SIM, anticorps stromal interaction molecule 1, anticorps stromal interaction molecule 1a, anticorps stromal interaction molecule 1 L homeolog, anticorps stromal interaction molecule 1b, anticorps STIM1, anticorps stim1, anticorps stim1a, anticorps stim1.L, anticorps stim1b, anticorps Stim1
    Sujet
    Function: Plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores. Acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/ORAI1.
    Subcellular location: Cell membrane, Single-pass type I membrane protein. Endoplasmic reticulum membrane, Single-pass type I membrane protein. Note: Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium.
    Tissue specificity: Ubiquitously expressed in various human primary cells and tumor cell lines. Also known as: STIM1, GOK.
    Pathways
    TCR Signaling, BCR Signaling
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