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Trpl (trpl) (4th Cytoplasmic Loop) anticorps

Détails pour le produit réf. ABIN351175, Fournisseur: Connectez-vous pour afficher
Antigène
  • CG1694
  • CG18345
  • DmTRPL
  • Dmel\\CG18345
  • TRPL
  • TrpL
  • Trpl
  • dTRPL
  • dTrpL
  • trp-l
Épitope
4th Cytoplasmic Loop
4
2
Reactivité
Mouche des fruits (Drosophila melanogaster)
6
Hôte
Lapin
6
Clonalité
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
6
4
Fournisseur
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Immunogène A synthetic peptide from 4th cytoplasmic loop of drosophila TRPL (Transient receptor potential like protein) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificité Specific for TRPL.
Autre désignation TRPL (trpl Antibody Extrait)
Sujet Function: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with trp-gamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins.
Subunit: Forms heteromultimers with trp-gamma and, to a lower extent, with trp. Interacts with FKBP59 in vivo and is found in the inaD signaling complex.
Subcellular location: Membrane, Multi-pass membrane protein. Note: In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions. Also known as: Transient receptor potential like protein, Transient-receptor-potential-like protein.
Domaine de recherche Neurology
Pathways
Indications d'application A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Conseil sur la manipulation Avoid freeze and thaw cycles.
Stock 4 °C/-20 °C
Stockage commentaire Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Date de péremption 12 months
Reference: Background Baehner, Frechter, Da Silva et al.: "Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current." dans: Neuron, Vol. 34, Issue 1, pp. 83-93, 2002 (PubMed).

Xu, Chien, Butler et al.: "TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL." dans: Neuron, Vol. 26, Issue 3, pp. 647-57, 2000 (PubMed).

Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." dans: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Chyb, Raghu, Hardie: "Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL." dans: Nature, Vol. 397, Issue 6716, pp. 255-9, 1999 (PubMed).

Lan, Brereton, Barritt: "The role of calmodulin-binding sites in the regulation of the Drosophila TRPL cation channel expressed in Xenopus laevis oocytes by ca2+, inositol 1,4,5-trisphosphate and GTP-binding proteins." dans: The Biochemical journal, Vol. 330 ( Pt 3), pp. 1149-58, 1998 (PubMed).

Xu, Li, Guggino et al.: "Coassembly of TRP and TRPL produces a distinct store-operated conductance." dans: Cell, Vol. 89, Issue 7, pp. 1155-64, 1997 (PubMed).

Phillips, Bull, Kelly: "Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene." dans: Neuron, Vol. 8, Issue 4, pp. 631-42, 1992 (PubMed).