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TRPM8 anticorps

TRPM8 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN351227
  • Antigène Voir toutes TRPM8 Anticorps
    TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
    Reactivité
    • 50
    • 15
    • 8
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 60
    • 1
    Lapin
    Clonalité
    • 58
    • 3
    Polyclonal
    Conjugué
    • 45
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TRPM8 est non-conjugé
    Application
    • 35
    • 26
    • 22
    • 16
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for TRPM8.
     Réactivité croisée
    Humain
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from human TRPM8 conjugated to blue carrier protein was used as the antigen.
    Isotype
    IgG
    Top Product
    Discover our top product TRPM8 Anticorps primaire
  • Indications d'application
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Malik, Bertolesi, McFarlane: "TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature." dans: Communications biology, Vol. 6, Issue 1, pp. 127, (2023) (PubMed).

  • Antigène
    TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
    Autre désignation
    TRPM8 (TRPM8 Produits)
    Synonymes
    anticorps TRPM8, anticorps trpp8, anticorps ltrpc6, anticorps trpm8b, anticorps LTRPC6, anticorps TRPP8, anticorps CMR1, anticorps LTrpC-6, anticorps Trp-p8, anticorps transient receptor potential cation channel subfamily M member 8, anticorps transient receptor potential cation channel subfamily M member 8b L homeolog, anticorps transient receptor potential cation channel, subfamily M, member 8, anticorps TRPM8, anticorps trpm8b.L, anticorps Trpm8
    Sujet
    FUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors. MISCELLANEOUS: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein. MISCELLANEOUS: Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.,Mammalian TRPM,Transient receptor potential cation channel subfamily M member 8, transient receptor potential-p8, Trp-p8, long transient receptor potential channel 6, LTrpC6, TRPP8, LTRPC6, MGC2849
    UniProt
    Q7Z2W7
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