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SMURF2 anticorps (N-Term)

SMURF2 Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN357471
  • Antigène Voir toutes SMURF2 Anticorps
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Épitope
    • 16
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 66
    • 28
    • 20
    Humain, Souris
    Hôte
    • 63
    • 3
    Lapin
    Clonalité
    • 55
    • 11
    Polyclonal
    Conjugué
    • 20
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SMURF2 est non-conjugé
    Application
    • 54
    • 34
    • 29
    • 18
    • 14
    • 13
    • 13
    • 12
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects SMURF2 at N-term.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SMURF2.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SMURF2 Anticorps primaire
  • Indications d'application
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Autre désignation
    SMURF2 (SMURF2 Produits)
    Synonymes
    anticorps SMURF2, anticorps 2810411E22Rik, anticorps AI558114, anticorps AI649275, anticorps RGD1310067, anticorps wu:fb82a11, anticorps wu:fc41c02, anticorps SMAD specific E3 ubiquitin protein ligase 2, anticorps SMAD specific E3 ubiquitin protein ligase 2 S homeolog, anticorps SMURF2, anticorps smurf2, anticorps Smurf2, anticorps smurf2.S
    Sujet
    SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83 % identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.Synonyms: E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, SMURF 2, SMURF-2
    Poids moléculaire
    86195 Da
    ID gène
    64750
    NCBI Accession
    NP_073576
    UniProt
    Q9HAU4
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