PAK2 anticorps (P21-Activated Kinase 2) (N-Term)

Details for Product anti-PAK2 Antibody No. ABIN360318, Fournisseur: Connectez-vous pour afficher
Antigène
  • pak2
  • cb422
  • kinase
  • zgc:91798
  • wu:fb71h01
  • si:dz198m22.1
  • pak65
  • pakgamma
  • PAK65
  • PAKgamma
  • 5330420P17Rik
  • A130002K10Rik
  • AI836325
  • D16Ertd269e
  • PAK-2
  • mKIAA4182
  • gamma-PAK
  • PAKI
  • Pak3
  • p21 (CDKN1A)-activated kinase 2a
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • pak2a
  • pak2
  • PAK2
  • Pak2
Épitope
N-Term
41
21
12
11
6
5
5
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
185
97
92
12
8
1
Hôte
Lapin
166
19
Clonalité
Polyclonal
Conjugué
Cet anticorp PAK2 est non-conjugé
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
166
101
76
35
19
6
6
4
2
2
2
1
Options
Fournisseur
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Supplier Product No.
Connectez-vous pour afficher
Immunogène This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PAK2.
Isotype Ig
Specificité This antibody reacts to PAK2.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Autre désignation PAK2 (PAK2 Antibody Extrait)
Sujet PAK2, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. PAK2 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Expression is ubiquitous, with higher levels seen in skeletal muscle, ovary, thymus and spleen. PAK2 is autophosphorylated when activated by CDC42/p21. The protein structure contains 1 CRIB domain.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58
ID gène 5062, 9606
UniProt Q13177
Domaine de recherche Cancer, Apoptosis/Necrosis, Tyrosine Kinases, Kinases/Phosphatases
Pathways Signalisation MAPK, Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Indications d'application ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (ABIN360318) anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody
 image for anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (ABIN360318) anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (Image 2)
Background publications Benner, Dennis, Masaracchia: "Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation." dans: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21121-8, 1995 (PubMed).

Martin, Bollag, McCormick, Abo: "A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20." dans: The EMBO journal, Vol. 14, Issue 9, pp. 1970-8, 1995 (PubMed).

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