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PKD2 anticorps (C-Term)

PKD2 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN360330
  • Antigène Voir toutes PKD2 Anticorps
    PKD2 (Protein Kinase D2 (PKD2))
    Épitope
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 49
    • 19
    • 9
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 45
    • 4
    • 1
    Lapin
    Clonalité
    • 39
    • 11
    Polyclonal
    Conjugué
    • 28
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PKD2 est non-conjugé
    Application
    • 37
    • 31
    • 27
    • 8
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes Protein Kinase D2 (PKD2).
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogène
    This PKC-D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Human PKD2. Genename: PRKD2
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PKD2 Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    PKD2 (Protein Kinase D2 (PKD2))
    Autre désignation
    PRKD2 / PKD2 (PKD2 Produits)
    Synonymes
    anticorps PKD2, anticorps nPKC-D2, anticorps AI325941, anticorps RGD1308054, anticorps PRKD2, anticorps protein kinase D2, anticorps serine/threonine-protein kinase D2, anticorps PRKD2, anticorps Prkd2, anticorps LOC100407181
    Sujet
    PKD2, a member of the polycystin family, functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. PKD2 interacts with PKD1, potentially through the C-terminal region. PKD1 requires the presence of PKD2 for stable expression. PKD2 also interacts with CD2AP. This protein is strongly expressed in ovary, fetal and adult kidney, testis, and small intestine, but is not detected in peripheral leukocytes. Defects in PKD2 are the cause of autosomal dominant polycystic kidney disease type II (ADPKD-2) which represent approximately 15 % of cases of autosomal dominant polycystic kidney disease, a common autosomal dominant genetic disease affecting about 1 out 1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. All mutations, scattered between exons 1 and 11, result in a truncated PKD2 that lacks both the calcium-binding EF-hand domain and the two cytoplasmic domains required for the interaction of PKD2 with PKD1 and with itself. ADPKD type II is clinically milder than ADPKD type I, but it has a deleterious impact on overall life expectancy.Synonyms: HSPC187, PKC-D2, Serine/threonine-protein kinase D2, nPKC-D2
    ID gène
    25865
    NCBI Accession
    NP_001073349
    UniProt
    Q9BZL6
    Pathways
    cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
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