LRP2 anticorps
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- Antigène Voir toutes LRP2 Anticorps
- LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LRP2 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Specificité
- This antibody recognizes Megalin/gp330.
- Purification
- Protein G Chromatography
- Immunogène
- Purified Human Megalin.
- Clone
- CD7D5
- Isotype
- IgG1
- Top Product
- Discover our top product LRP2 Anticorps primaire
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- Indications d'application
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Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS, pH 6.0 without preservatives or stabilizers
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C.
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- Antigène
- LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
- Autre désignation
- LRP2 (LRP2 Produits)
- Synonymes
- anticorps im:680590, anticorps lrp2, anticorps dbs, anticorps gp330, anticorps megalin, anticorps DBS, anticorps GP330, anticorps AI315343, anticorps AW536255, anticorps D230004K18Rik, anticorps Gp330, anticorps Megalin, anticorps LDL receptor related protein 2, anticorps low density lipoprotein receptor-related protein 2a, anticorps low density lipoprotein receptor-related protein 2, anticorps low-density lipoprotein receptor-related protein 2, anticorps LDL receptor related protein 2 L homeolog, anticorps LRP2, anticorps lrp2a, anticorps LRP2.3, anticorps lrp2.L, anticorps LOC100183506, anticorps lrp2, anticorps Lrp2
- Sujet
- Megalin, also called Lipoprotein receptor-related protein-2 (LRP2) or glycoprotein 330, is a 600- kDa transmembrane protein belonging to the LDL-receptor family. Members of this receptor family are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin was first discovered in 1982 as the pathogenic antigen of Heymann nephritis. The complete cDNA sequences have been characterized for rat and human Megalin. The protein contains a single transmembrane domain, is known to act as an endocytic receptor and is expressed primarily on the apical membrane domain of epithelial cells. Both the protein and its mRNA have been identified in human parathyroid cells, placental cytotrophoblasts and epididymal epithelial cells. The protein is also expressed in mammary epithelia, thyroid follicular cells, yolk sacs, the ciliary body of the eye, the intestinal brush border, the male reproductive tract, uterus and oviduct, and gallbladder epithelium. In addition, immortalised foetal rat alveolar pretype II cells, adult rat type II pneumocytes and human type II cells have all been reported to express megalin. It has been proposed that in adult lung megalin may be important in supplying vitamin E to type II pneumocytes. Specifically, Megalin mediates the uptake of apolipoprotein J, which is a binding protein for the beta-Amyloid peptide, a peptide implicated in Alzheimer's disease. It is also involved in renal uptake of Angiotensin and the reabsorption of various molecules including calcium, vitamin B12 and vitamin D.Synonyms: Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, Megalin
- ID gène
- 4036
- NCBI Accession
- NP_004516
- UniProt
- P98164
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport
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