Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

GRIN2B anticorps (pTyr1336)

GRIN2B Reactivité: Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361484
  • Antigène Voir toutes GRIN2B Anticorps
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Épitope
    • 33
    • 30
    • 24
    • 23
    • 22
    • 20
    • 16
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1336
    Reactivité
    • 197
    • 183
    • 154
    • 30
    • 27
    • 24
    • 10
    • 10
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Hôte
    • 205
    • 40
    • 1
    Lapin
    Clonalité
    • 207
    • 39
    Polyclonal
    Conjugué
    • 109
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp GRIN2B est non-conjugé
    Application
    • 199
    • 68
    • 65
    • 65
    • 46
    • 43
    • 34
    • 24
    • 24
    • 18
    • 16
    • 11
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for ~180k NMDAR NR2B subunit protein phosphorylated at Tyr1336. Immunolabeling of the NMDAR NR2B subunit band is blocked by (-phosphatase treatment.
     Réactivité croisée
    Souris, Rat (Rattus)
    Homologie
    human, non-human primate
    Purification
    Antigen Affinity Purified from Pooled Serum
    Immunogène
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1336 conjugated to KLH
    Top Product
    Discover our top product GRIN2B Anticorps primaire
  • Indications d'application
    Recommended Dilution: WB: 1:1000 IHC: 1:400 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Stock
    -20 °C
  • Jiang, Knox, Pathipati, Ferriero: "Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain." dans: Neuroscience letters, Vol. 503, Issue 3, pp. 215-9, (2011) (PubMed).

    Hicklin, Wu, Radcliffe, Freund, Goebel-Goody, Correa, Proctor, Lombroso, Browning: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).

    Chernova, Steinert, Guerin, Nicotera, Forsythe, Smith: "Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 32, pp. 8475-85, (2007) (PubMed).

  • Antigène
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Autre désignation
    GRIN2B (GRIN2B Produits)
    Synonymes
    anticorps NMDAR2B, anticorps GluN2B, anticorps MRD6, anticorps NR2B, anticorps hNR3, anticorps nmdar2b, anticorps nr2b, anticorps AW490526, anticorps Nmdar2b, anticorps glutamate ionotropic receptor NMDA type subunit 2B, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog, anticorps glutamate receptor, ionotropic, NMDA2B (epsilon 2), anticorps GRIN2B, anticorps Grin2b, anticorps grin2b.L
    Sujet
    The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer?s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Phosphorylation of Tyr1336 is thought to potentiate NMDA receptor-dependent influx of calcium (Takasu et al., 2002) and ischemia may also increase the phosphorylation of this site (Takagi et al., 2003). Anti-Phospho-Tyr1336 NMDA Receptor NR2B Subunit Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1336 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1336 NMDA NR2B antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
    Poids moléculaire
    '180 kDa
    ID gène
    24410
    UniProt
    Q00960
    Pathways
    Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Vous êtes ici:
Support technique