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HMOX1 anticorps

HMOX1 Reactivité: Humain WB, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361673
  • Antigène Voir toutes HMOX1 Anticorps
    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
    Reactivité
    • 117
    • 70
    • 44
    • 15
    • 11
    • 9
    • 9
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 128
    • 48
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 125
    • 55
    Polyclonal
    Conjugué
    • 79
    • 21
    • 16
    • 9
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HMOX1 est non-conjugé
    Application
    • 152
    • 79
    • 57
    • 54
    • 52
    • 42
    • 23
    • 11
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    Detects ~32 kDa.
     Réactivité croisée
    Chien, Humain, Souris, Rat
    Purification
    Protein A Purified
    Immunogène
    Human heme-oxygenase (HO-1) synthetic multiple antigenic peptide
    Top Product
    Discover our top product HMOX1 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN361673 was sufficient for detection of HO-1 in 10 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Antigène
    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
    Autre désignation
    HO-1 (HMOX1 Produits)
    Synonymes
    anticorps HMOX1, anticorps ARABIDOPSIS THALIANA HEME OXYGENASE 1, anticorps ATHO1, anticorps F18A8.4, anticorps F18A8_4, anticorps GENOMES UNCOUPLED 2, anticorps GUN2, anticorps HEME OXYGENASE, anticorps HEME OXYGENASE 1, anticorps HEME OXYGENASE 6, anticorps HO1, anticorps HY1, anticorps HY6, anticorps PLASTID HEME OXYGENASE, anticorps REVERSAL OF THE DET PHENOTYPE 4, anticorps HO-1, anticorps wu:fc27c04, anticorps zgc:65984, anticorps D8Wsu38e, anticorps Hemox, anticorps Hmox, anticorps Hsp32, anticorps HEOXG, anticorps Heox, anticorps Ho-1, anticorps Ho1, anticorps hsp32, anticorps MGC132176, anticorps Hmox1, anticorps HMOX1D, anticorps HSP32, anticorps bK286B10, anticorps heme oxygenase 1, anticorps Plant heme oxygenase (decyclizing) family protein, anticorps Heme oxygenase, anticorps heme oxygenase, anticorps heme oxygenase 1, chloroplastic, anticorps heme oxygenase 1a, anticorps heme oxygenase 1 L homeolog, anticorps HMOX1, anticorps TED4, anticorps ho1, anticorps P9301_RS17555, anticorps A9601_RS17590, anticorps MAE_RS06565, anticorps HO1, anticorps hmox1a, anticorps CPE0214, anticorps Cyan7425_2962, anticorps Hmox1, anticorps hmox1.L, anticorps AM1_C0205, anticorps CC1G_11686, anticorps CpipJ_CPIJ007246
    Sujet
    Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator, biliverdin and bilirubin are potent antioxidants, and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3, however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).
    ID gène
    3162
    NCBI Accession
    NP_002124
    UniProt
    P09601
    Pathways
    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
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