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Lysine (lys) (acetylated) anticorps (HRP)

lys WB, ICC, IF, IP, ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN361692
  • Antigène
    Lysine (lys)
    Épitope
    • 22
    • 11
    acetylated
    Reactivité
    Veuillez nous consulter SVP
    Hôte
    • 21
    • 12
    Lapin
    Clonalité
    • 21
    • 12
    Polyclonal
    Conjugué
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    HRP
    Application
    • 33
    • 32
    • 32
    • 32
    • 32
    • 11
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA
    Specificité
    Detects proteins containing acetylated lysine residues. No reaction to non-acetylated proteins.
    Purification
    Protein A Purified
    Immunogène
    Acetylated KLH Conjugated
  • Indications d'application
    • WB (1:250)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1/250 dilution of SPC-157 was sufficient to detect the acetylated histone from TSA treated mouse spleen cell in western blot analysis.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    Lysine (lys)
    Autre désignation
    Lysine
    Synonymes
    anticorps lysine, anticorps lys
    Classe de substances
    Amino Acid
    Sujet
    Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anti-cancer drugs currently in development (5).
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