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Phosphoserine anticorps

WB, ELISA, IP, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361725
  • Antigène Tous les produits Phosphoserine
    Phosphoserine
    Reactivité
    Veuillez nous consulter SVP
    Hôte
    • 29
    • 14
    Lapin
    Clonalité
    • 30
    • 13
    Polyclonal
    Conjugué
    • 17
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Phosphoserine est non-conjugé
    Application
    • 41
    • 20
    • 18
    • 10
    • 6
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    Detects proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.
    Purification
    Peptide Affinity Purified
    Immunogène
    Phosphoserine conjugated to KLH, and phosvitin mixture
  • Indications d'application
    • WB (1:500)
    • ICC/IF (1:50)
    • ELISA (1:250)
    • IP (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    2 μg/ml of ABIN361725 was sufficient for detection of phosphorylation signal in western blot analysis using human MMRU cells treated with 0.1 μM okadaic acid.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.01 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Shalem-Cohavi, Beery, Nordenberg, Rozovski, Raanani, Lahav, Uziel: "The Effects of Proteasome Inhibitors on Telomerase Activity and Regulation in Multiple Myeloma Cells." dans: International journal of molecular sciences, Vol. 20, Issue 10, (2019) (PubMed).

    Uziel, Cohen, Beery, Nordenberg, Lahav: "The effect of Bortezomib and Rapamycin on Telomerase Activity in Mantle Cell Lymphoma." dans: Translational oncology, Vol. 7, Issue 6, pp. 741-51, (2014) (PubMed).

  • Antigène
    Phosphoserine
    Abstract
    Phosphoserine Produits
    Classe de substances
    Amino Acid
    Sujet
    Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine, others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).
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