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LAMP2 anticorps

LAMP2 Reactivité: Souris WB, IP, ICC, IF Hôte: Rat Monoclonal GL2A7 unconjugated
N° du produit ABIN361745
  • Antigène Voir toutes LAMP2 Anticorps
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Reactivité
    • 113
    • 78
    • 36
    • 16
    • 3
    • 3
    • 2
    • 1
    Souris
    Hôte
    • 86
    • 42
    • 34
    Rat
    Clonalité
    • 85
    • 76
    Monoclonal
    Conjugué
    • 60
    • 20
    • 20
    • 15
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LAMP2 est non-conjugé
    Application
    • 115
    • 56
    • 53
    • 37
    • 34
    • 29
    • 28
    • 15
    • 13
    • 13
    • 12
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    Detects ~100-110 kDa.
     Réactivité croisée
    Humain, Souris, Lapin
    Purification
    Protein G Purified
    Immunogène
    Purified preparation of mouse liver lysosomal membranes
    Clone
    GL2A7
    Isotype
    IgG1
    Top Product
    Discover our top product LAMP2 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:500)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN361745 was sufficient for detection of LAMP2 in 20 μg of rat liver microsomes by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Antigène
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Autre désignation
    LAMP2 (LAMP2 Produits)
    Synonymes
    anticorps CD107b, anticorps LAMP-2, anticorps LAMPB, anticorps LGP110, anticorps Lamp-2, anticorps Lamp-2a, anticorps Lamp-2b, anticorps Lamp-2c, anticorps Mac3, anticorps cd107b, anticorps lamp-2, anticorps lampb, anticorps LAMP2, anticorps lamp2, anticorps DKFZp459J126, anticorps LGP-B, anticorps sb:cb587, anticorps wu:fb14a06, anticorps zgc:103532, anticorps lysosomal associated membrane protein 2, anticorps lysosomal-associated membrane protein 2, anticorps lysosomal-associated membrane protein 2 S homeolog, anticorps lysosomal membrane glycoprotein 2, anticorps LAMP2, anticorps Lamp2, anticorps lamp2.S, anticorps lamp2
    Sujet
    Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis (4). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6). LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).
    ID gène
    16784
    NCBI Accession
    NP_001017959
    UniProt
    P17047
    Pathways
    Autophagy
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