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BIM anticorps

BCL2L11 Reactivité: Humain WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361751
  • Antigène Voir toutes BIM (BCL2L11) Anticorps
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    Reactivité
    • 179
    • 101
    • 91
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 167
    • 9
    • 5
    • 1
    Lapin
    Clonalité
    • 152
    • 30
    Polyclonal
    Conjugué
    • 69
    • 16
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BIM est non-conjugé
    Application
    • 124
    • 65
    • 51
    • 28
    • 25
    • 22
    • 15
    • 14
    • 14
    • 13
    • 10
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~23 kDa.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein A Purified
    Immunogène
    Internal central amino acids of human Bim
    Top Product
    Discover our top product BCL2L11 Anticorps primaire
  • Indications d'application
    • WB (1:400)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    2.5 μg/ml of ABIN361751 was sufficient for detection of Bim in 20 μg of K562 cell lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Antigène
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    Autre désignation
    BIM (BCL2L11 Produits)
    Synonymes
    anticorps bim, anticorps BAM, anticorps BIM, anticorps BOD, anticorps 1500006F24Rik, anticorps Bim, anticorps Bod, anticorps BimL, anticorps BIMEL, anticorps BCL2-like 11, anticorps BCL2 like 11, anticorps BCL2-like 11 (apoptosis facilitator), anticorps bcl2l11, anticorps BCL2L11, anticorps Bcl2l11
    Sujet
    Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).
    ID gène
    10018
    NCBI Accession
    NP_619527
    UniProt
    O43521
    Pathways
    Signalisation PI3K-Akt, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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