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CRYAB anticorps

CRYAB Reactivité: Humain WB, ELISA, IF, ICC Hôte: Souris Monoclonal 1A7-D5 unconjugated
N° du produit ABIN361809
  • Antigène Voir toutes CRYAB Anticorps
    CRYAB (Crystallin, alpha B (CRYAB))
    Reactivité
    • 131
    • 97
    • 84
    • 15
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 159
    • 33
    • 2
    • 1
    Souris
    Clonalité
    • 152
    • 43
    Monoclonal
    Conjugué
    • 77
    • 11
    • 11
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CRYAB est non-conjugé
    Application
    • 140
    • 74
    • 66
    • 66
    • 57
    • 36
    • 33
    • 33
    • 17
    • 15
    • 11
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~20 kDa (Predicted mol. weight is ~21 kDa). Does not cross-react with αA-crystallin, βL-crystallin, βH-crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
     Réactivité croisée
    Boeuf (Vache), Humain, Porc, Rat
    Purification
    Protein G Purified
    Immunogène
    Native Alpha B Crystallin
    Clone
    1A7-D5
    Isotype
    IgG1
    Top Product
    Discover our top product CRYAB Anticorps primaire
  • Indications d'application
    • WB (1:2000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    0.5 μg/ml of ABIN361808 was sufficient for detection of 50 ng purified alpha B crystalline by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Piccolella, Crippa, Cristofani, Rusmini, Galbiati, Cicardi, Meroni, Ferri, Morelli, Carra, Messi, Poletti: "The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells." dans: Oncotarget, Vol. 8, Issue 6, pp. 10400-10415, (2018) (PubMed).

    Akkad, Corpeno, Larsson: "Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model." dans: PLoS ONE, Vol. 9, Issue 4, pp. e92622, (2014) (PubMed).

    Ochala, Gustafson, Diez, Renaud, Li, Aare, Qaisar, Banduseela, Hedström, Tang, Dworkin, Ford, Nair, Perera, Gautel, Larsson: "Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms." dans: The Journal of physiology, Vol. 589, Issue Pt 8, pp. 2007-26, (2011) (PubMed).

    Aare, Ochala, Norman, Radell, Eriksson, Göransson, Chen, Hoffman, Larsson: "Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model." dans: Physiological genomics, Vol. 43, Issue 24, pp. 1334-50, (2011) (PubMed).

    Banduseela, Ochala, Chen, Göransson, Norman, Radell, Eriksson, Hoffman, Larsson: "Gene expression and muscle fiber function in a porcine ICU model." dans: Physiological genomics, Vol. 39, Issue 3, pp. 141-59, (2009) (PubMed).

  • Antigène
    CRYAB (Crystallin, alpha B (CRYAB))
    Autre désignation
    Alpha B Crystallin (CRYAB Produits)
    Synonymes
    anticorps CMD1II, anticorps CRYA2, anticorps CTPP2, anticorps CTRCT16, anticorps HSPB5, anticorps MFM2, anticorps Crya-2, anticorps Crya2, anticorps HspB5, anticorps AACRYA, anticorps CRYAB, anticorps cryab, anticorps cryab2, anticorps wu:fe37f08, anticorps zgc:91937, anticorps crystallin alpha B, anticorps crystallin, alpha B, anticorps hypothetical protein, anticorps crystallin, alpha B, a, anticorps crystallin, alpha B, b, anticorps CRYAB, anticorps Cryab, anticorps ZK1128.7, anticorps cryaba, anticorps cryabb
    Sujet
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
    ID gène
    1410
    NCBI Accession
    NP_001876
    UniProt
    P02511
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