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HSP70 anticorps

HSP70 Reactivité: Humain WB, ELISA, IHC, IF, IP, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361820
  • Antigène Voir toutes HSP70 Anticorps
    HSP70 (Heat Shock Protein 70 (HSP70))
    Reactivité
    • 323
    • 199
    • 165
    • 71
    • 62
    • 53
    • 52
    • 52
    • 36
    • 33
    • 29
    • 29
    • 28
    • 23
    • 20
    • 18
    • 15
    • 13
    • 12
    • 12
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 206
    • 150
    • 13
    • 11
    • 11
    Lapin
    Clonalité
    • 228
    • 162
    Polyclonal
    Conjugué
    • 112
    • 31
    • 28
    • 26
    • 24
    • 20
    • 19
    • 18
    • 18
    • 18
    • 12
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSP70 est non-conjugé
    Application
    • 374
    • 159
    • 142
    • 122
    • 122
    • 110
    • 101
    • 66
    • 62
    • 61
    • 41
    • 33
    • 22
    • 21
    • 21
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificité
    Detects a ~70 kDa. May cross-react with HSC70 at lower dilutions.
     Réactivité croisée
    Beluga, Carpe, Corail, Boeuf (Vache), Chien, Poisson, Cobaye, Hamster, Humain, Leishmania amazonensis, Singe, Souris, Porc, Plantes, Rat, Requin, Mouton
    Purification
    Peptide Affinity Purified
    Immunogène
    Recombinant Full length HSP70 Protein
    Top Product
    Discover our top product HSP70 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • IP (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1:1000 dilution of ABIN361820 was sufficient for detection of HSP70 in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Woodford, Dunn, Blanden, Capriotti, Loiselle, Prodromou, Panaretou, Hughes, Smith, Ackerman, Haystead, Loh, Bourboulia, Schmidt, Marston Linehan, Bratslavsky, Mollapour: "The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding." dans: Nature communications, Vol. 7, pp. 12037, (2018) (PubMed).

    Codonho, Costa, Peloso, Joazeiro, Gadelha, Giorgio: "HSP70 of Leishmania amazonensis alters resistance to different stresses and mitochondrial bioenergetics." dans: Memórias do Instituto Oswaldo Cruz, (2017) (PubMed).

    Watanabe, Tsujimura, Taguchi, Tanaka: "HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis." dans: Autophagy, Vol. 13, Issue 1, pp. 133-148, (2017) (PubMed).

    Silverstein, Ordanes, Wylie, Files, Milligan, Presley, Kavanagh: "Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice." dans: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, Issue 7, pp. 800-8, (2015) (PubMed).

  • Antigène
    HSP70 (Heat Shock Protein 70 (HSP70))
    Autre désignation
    HSP70 (HSP70 Produits)
    Synonymes
    anticorps APG-2, anticorps HS24/P52, anticorps HSPH2, anticorps RY, anticorps hsp70, anticorps hsp70RY, anticorps CG31354, anticorps HSP70, anticorps Hsp70Bb, anticorps hsp70B, anticorps hsp70Bb-prime, anticorps DmelCG5834, anticorps CG5834, anticorps HSPA1, anticorps HSP70B', anticorps HSPA6, anticorps ARABIDOPSIS HEAT SHOCK PROTEIN 70, anticorps ATHSP70, anticorps heat shock protein 70, anticorps LOC100305036, anticorps hsc70, anticorps Hsp70, anticorps Hsp70-1, anticorps Hsp70.1, anticorps hsp68, anticorps Hsp110, anticorps irp94, anticorps HSP70-2, anticorps HSPA1B, anticorps HSPA2, anticorps hsp70-5, anticorps HSP70-1, anticorps HSP70.1, anticorps HSP70.2, anticorps heat shock protein family A (Hsp70) member 4, anticorps CG5834 gene product from transcript CG5834-RA, anticorps heat shock protein 70, anticorps heat shock protein family A (Hsp70) member 6, anticorps heat shock 70kDa protein 2, anticorps heat shock 70 kD protein cognate, anticorps Hsp70 family chaperone, anticorps Heat shock protein 70, anticorps Heat shock protein 70, putative, anticorps heat shock protein 1B, anticorps heat shock protein family A member 4, anticorps heat shock 70kDa protein 1A, anticorps heat shock protein 1, anticorps Heat Shock Protein, anticorps heat shock cognate 70-kd protein, anticorps Heat shock 70 kDa protein 1A, anticorps HSPA4, anticorps Hsp70Bbb, anticorps HSP70, anticorps HSPA6, anticorps HSPA2, anticorps PCC7424_2419, anticorps Isop_1041, anticorps CGB_C3390W, anticorps Bacsa_1698, anticorps dnaK-B, anticorps LOC100305036, anticorps Hspa1b, anticorps Hspa4, anticorps HSPA1A, anticorps hsp1, anticorps hsp-70, anticorps hsp70, anticorps LOC108348108
    Sujet
    HSP70 genes encode abundant heat-inducible 70- kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 50 % identity (1, 2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATPbinding domain displays multiple features of nucleotide binding proteins (5). All HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
    ID gène
    3303
    NCBI Accession
    NP_005336
    UniProt
    P0DMV8, P0DMV9
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