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EIF2AK2 anticorps (pThr451)

EIF2AK2 Reactivité: Humain IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN362374
  • Antigène Voir toutes EIF2AK2 Anticorps
    EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
    Épitope
    • 46
    • 34
    • 11
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr451
    Reactivité
    • 127
    • 74
    • 49
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 121
    • 11
    Lapin
    Clonalité
    • 107
    • 25
    Polyclonal
    Conjugué
    • 79
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Cet anticorp EIF2AK2 est non-conjugé
    Application
    • 111
    • 46
    • 41
    • 40
    • 38
    • 31
    • 22
    • 17
    • 10
    • 10
    • 9
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC)
    Specificité
    The antibody detects endogenous level of PKR only when phosphorylated at threonine 451.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    Peptide sequence around phosphorylation site of pThr451 (K-G-T (p) -L-R) derived from Human PKR. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
    Top Product
    Discover our top product EIF2AK2 Anticorps primaire
  • Indications d'application
    Immunohistochemistry: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Laing, Wang, Briazova, Zhang, Wang, Zheng, Gow, Chen, Rajagopalan, Chen, Sun, Zhang: "Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues." dans: American journal of physiology. Cell physiology, Vol. 299, Issue 4, pp. C736-49, (2010) (PubMed).

  • Antigène
    EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
    Autre désignation
    PKR (EIF2AK2 Produits)
    Synonymes
    anticorps PKR, anticorps pkr, anticorps EIF2AK2, anticorps DKFZp469K1934, anticorps EIF2AK1, anticorps PRKR, anticorps 2310047A08Rik, anticorps 4732414G15Rik, anticorps AI467567, anticorps AI747578, anticorps Pkr, anticorps Prkr, anticorps Tik, anticorps eukaryotic translation initiation factor 2 alpha kinase 2, anticorps eukaryotic translation initiation factor 2-alpha kinase 2, anticorps EIF2AK2, anticorps eif2ak2, anticorps Eif2ak2
    Sujet
    Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
    Poids moléculaire
    68 kDa
    NCBI Accession
    NP_001129
    UniProt
    P19525
    Pathways
    Réparation de l'ADN, ER-Nucleus Signaling, Hepatitis C
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