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TRKB anticorps (pTyr515)

NTRK2 Reactivité: Humain, Rat, Souris IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN362424
  • Antigène Voir toutes TRKB (NTRK2) Anticorps
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Épitope
    • 16
    • 15
    • 12
    • 12
    • 10
    • 9
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr515
    Reactivité
    • 134
    • 91
    • 86
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 139
    • 9
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 131
    • 23
    Polyclonal
    Conjugué
    • 85
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp TRKB est non-conjugé
    Application
    • 111
    • 55
    • 50
    • 20
    • 19
    • 18
    • 15
    • 14
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF)
    Specificité
    The antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 515.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    Peptide sequence around phosphorylation site of pTyr515 (P-Q-Y (p) -F-G) derived from Human TrkB. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
    Top Product
    Discover our top product NTRK2 Anticorps primaire
  • Indications d'application
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Wu, Hill, Klug, van den Buuse: "Sex-specific and region-specific changes in BDNF-TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice." dans: Brain research, Vol. 1452, pp. 10-7, (2012) (PubMed).

    Li, Liu: "The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice." dans: Acta pharmacologica Sinica, Vol. 31, Issue 3, pp. 265-72, (2010) (PubMed).

  • Antigène
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Autre désignation
    TrkB (NTRK2 Produits)
    Synonymes
    anticorps trkb, anticorps trkb-b, anticorps xtrkb, anticorps si:ch211-220b11.1, anticorps trkB2, anticorps NTRK2, anticorps ntrk2, anticorps gp145-trkb, anticorps TRKB, anticorps GP145-TrkB, anticorps trk-B, anticorps AI848316, anticorps C030027L06Rik, anticorps Tkrb, anticorps trkB, anticorps RATTRKB1, anticorps TRKB1, anticorps Trk-B, anticorps TrkB, anticorps neurotrophic receptor tyrosine kinase 2, anticorps neurotrophic receptor tyrosine kinase 2 L homeolog, anticorps neurotrophic tyrosine kinase, receptor, type 2b, anticorps neurotrophic receptor tyrosine kinase 2 S homeolog, anticorps neurotrophic tyrosine kinase, receptor, type 2, anticorps NTRK2, anticorps ntrk2.L, anticorps ntrk2b, anticorps ntrk2.S, anticorps ntrk2, anticorps Ntrk2
    Sujet
    Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
    Poids moléculaire
    140 kDa
    NCBI Accession
    NP_001007
    UniProt
    Q16620
    Pathways
    Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
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