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HDAC4/HDAC5/HDAC9 anticorps (pSer246)

Reactivité: Humain, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN362452
  • Antigène Tous les produits HDAC4/HDAC5/HDAC9
    HDAC4/HDAC5/HDAC9 (HDAC4,HDAC5,HDAC9)
    Épitope
    • 9
    • 9
    • 9
    • 1
    • 1
    • 1
    • 1
    pSer246
    Reactivité
    • 20
    • 11
    • 1
    Humain, Souris
    Hôte
    • 20
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp HDAC4/HDAC5/HDAC9 est non-conjugé
    Application
    • 6
    • 5
    • 5
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    The antibody detects endogenous level of HDAC4/HDAC5/HDAC9 only when phosphorylated at serine 246/259/220.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    Peptide sequence around phosphorylation site of pSer246, 259, 220 (T-A-S (p) -EP) derived from Human HDAC4, HDAC5, HDAC9. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
  • Indications d'application
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    HDAC4/HDAC5/HDAC9 (HDAC4,HDAC5,HDAC9)
    Autre désignation
    HDAC4/HDAC5/HDAC9 (HDAC4/HDAC5/HDAC9 Produits)
    Synonymes
    anticorps AHO3, anticorps BDMR, anticorps HA6116, anticorps HD4, anticorps HDAC-4, anticorps HDAC-A, anticorps HDACA, anticorps histone deacetylase 4, anticorps HDAC4
    Sujet
    Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs, classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.
    Poids moléculaire
    124 kDa
    NCBI Accession
    NP_055522, NP_001015
    UniProt
    Q9UKV0
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