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MAP2K6 anticorps (AA 205-209)

MAP2K6 Reactivité: Humain, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN362761
  • Antigène Voir toutes MAP2K6 Anticorps
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    Épitope
    • 19
    • 15
    • 11
    • 9
    • 9
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 205-209
    Reactivité
    • 74
    • 62
    • 38
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 87
    • 6
    • 2
    Lapin
    Clonalité
    • 89
    • 6
    Polyclonal
    Conjugué
    • 46
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp MAP2K6 est non-conjugé
    Application
    • 82
    • 41
    • 27
    • 27
    • 15
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Specificité
    The antibody detects endogenous level of total MKK6 protein.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
    Immunogène
    Peptide sequence around AA 205-209 (V-D-S-V-A) derived from Human MKK6. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotype
    IgG
    Top Product
    Discover our top product MAP2K6 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    Autre désignation
    MKK6 (MAP2K6 Produits)
    Synonymes
    anticorps MAPKK6, anticorps MEK6, anticorps MKK6, anticorps PRKMK6, anticorps SAPKK-3, anticorps SAPKK3, anticorps Mkk6, anticorps Prkmk6, anticorps MKK3, anticorps map2k3, anticorps zMKK3, anticorps map2k6, anticorps mitogen-activated protein kinase kinase 6, anticorps mitogen-activated protein kinase kinase 6 L homeolog, anticorps MAP2K6, anticorps Map2k6, anticorps map2k6, anticorps map2k6.L
    Sujet
    MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
    Poids moléculaire
    41 kDa
    NCBI Accession
    NP_002749
    UniProt
    P52564
    Pathways
    Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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